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Alkylating agents

Metformin for Breast Cancer (HERMET Trial)

Phase 2
Waitlist Available
Led By Qamar Khan, MD
Research Sponsored by Qamar Khan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Study participants must be cT1c - cT4a-d, any node (N), no metastases (M0). Any tumor (T) is allowed if node positive (biopsy proven and HER2 positive) including no primary invasive cancer or only ductal carcinoma in situ (DCIS). Metastatic workup is not required.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 weeks after last chemotherapy treatment
Awards & highlights

HERMET Trial Summary

This trial is testing whether metformin can help treat HER2 positive breast cancer when added to standard chemotherapy.

Eligible Conditions
  • HER2-positive Breast Cancer

HERMET Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have been diagnosed with early to advanced stage cancer that has not spread to other parts of your body. If your cancer has spread to your lymph nodes and you have a specific type of gene called HER2, you may still be eligible for the study. You do not need additional tests to check for cancer spread.

HERMET Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 weeks after last chemotherapy treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 weeks after last chemotherapy treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pathologic complete response (pCR)

Side effects data

From 2015 Phase 4 trial • 156 Patients • NCT02002221
13%
Nasopharyngitis
10%
Hyperhidrosis
9%
Hunger
9%
Tremor
8%
Asthenia
6%
Hypoglycaemia
1%
Squamous cell carcinoma of the tongue
1%
Femoral neck fracture
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vildagliptin (LAF237)
Placebo

HERMET Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Chemotherapy plus MetforminExperimental Treatment2 Interventions
TCH+P plus metformin
Group II: Chemotherapy OnlyActive Control1 Intervention
Taxotere, Carboplatin, Herceptin + Pertuzumab (TCH+P)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metformin
2006
Completed Phase 4
~2430

Find a Location

Who is running the clinical trial?

Qamar KhanLead Sponsor
3 Previous Clinical Trials
481 Total Patients Enrolled
3 Trials studying Breast Cancer
481 Patients Enrolled for Breast Cancer
Qamar Khan, MD5.011 ReviewsPrincipal Investigator - University of Kansas Medical Center
Medical School - Andhra Medical College, Bachelor of Medicine, Bachelor of Surgery
University of Kansas Medical Center, Residency in Internal Medicine
6 Previous Clinical Trials
918 Total Patients Enrolled
4 Trials studying Breast Cancer
853 Patients Enrolled for Breast Cancer
5Patient Review
It was great!

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When was Metformin accepted by the FDA as a medication?

"So far, Metformin has shown signs of safety in clinical trials but not efficacy, giving it a score of 2."

Answered by AI

What else is known about Metformin from other investigations?

"Currently, 1335 clinical trials are ongoing that involve metformin. Of these, 410 are in phase 3. Many of the trials taking place in Seattle, Washington, but there are 74753 locations running studies for metformin globally."

Answered by AI

What are the primary indications for Metformin?

"Metformin is frequently used to treat non-hodgkin lymphoma. However, Metformin can also be used as part of the initial treatment for diet and exercise not sufficient for diabetes control and metastatic bladder cancer."

Answered by AI

Are we still recruiting volunteers for this experiment?

"This study, which is currently recruiting participants, was originally posted on August 15th, 2017 and was last updated on December 4th, 2021."

Answered by AI

What is the total number of volunteers for this test?

"That is correct, the online information portal clinicaltrials.gov has indicated that this trial is still seeking patients. The posting went up on 8/15/2017 and was edited as recently as 12/4/2021. They are looking for 100 individuals to participate at 6 different hospitals or clinics."

Answered by AI
~13 spots leftby Mar 2025