This trial is evaluating whether Ecological Momentary Intervention will improve 1 primary outcome, 1 secondary outcome, and 1 other outcome in patients with Methamphetamine Use Disorder. Measurement will happen over the course of Every week from enrollment to the end of treatment at 12 weeks.
This trial requires 54 total participants across 2 different treatment groups
This trial involves 2 different treatments. Ecological Momentary Intervention is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
This paper explains the multiple causes of MUD and provides a framework outlining how the various environmental and genetic factors that define one can interact to alter the individual's propensity to use MUD.
Several behavioral symptoms of MUD are potentially relevant to diagnosing methamphetamine use disorder; however, other signs and symptoms of MUD may become more apparent as MUD progresses.
The diagnosis of methamphetamine use disorder is not recommended due to a high rate of comorbidity with other substance use disorders, limited diagnostic utility for methamphetamine use alone, and high prevalence of methamphetamine use throughout the population. Nevertheless, treatment for methamphetamine-only use is warranted because the diagnosis of a lifetime cannabis use disorder is associated with an 80% lifetime risk of methamphetamine use disorder.
Long-term remission of MUD has not been reported previously. We demonstrate that MUD is frequently associated with a chronic psychostimulant misuse, but that a relatively small number of MUD patients exhibit a form of psychostimulant dependence that can be managed by psychotherapy.
The prevalence of MUD in the U.S. is 1.36 per 1000. The highest prevalence was observed among black and Hispanic persons. The lifetime prevalence of SUD was 10.0% for all race and ethnic groups in this sample.
This paper provides a compendium of the common treatments that have been studied for mUD. Although the evidence base for many of the treatments is sparse, it can offer a preliminary guide to the most promising future treatments. The treatment of severe withdrawal symptoms is extremely important, with the potential for profound improvement both in terms of clinical outcome and reduction in the associated high levels of psychiatric distress and disability. The clinical utility of long-term CBT is currently unclear. Some preliminary evidence suggests that psychological interventions can produce long-term remission, while antidepressant drugs alone may not.
EMIs are beneficial for drug abuse in individuals who are less motivated to quit and who have developed a more stable pattern of illicit drug abuse. No statistically significant effects of EMIs were observed in treatments combined with other treatments.
Despite their limited design, two clinical studies suggest that there may be a benefit from the use of an MUD in the treatment of MUD. Results from a recent clinical trial suggest that the presence of alcohol or drug dependence would influence the outcome of this study. We agree that a randomized double-blind, placebo-controlled study powered expressly for this purpose would be needed to definitively answer this important question.
EcOP is a feasible intervention for individuals with problematic substance use. The utility of EcOP was demonstrated in three studies, involving individuals with an alcohol, cocaine, cocaine use disorder, opiate, and methamphetamine addiction. EcOP can be used to address key addiction problems and reduce relapse.
Interventions that target quality of life for MUD clients may be beneficial. Ecological momentary interventions provide a uniquely promising approach to improving quality of life in persons with MUD.
While a limited number of studies on methamphetamine use disorder (MUD) have been published, only recently have some important findings been made. As an example, the current literature suggests that some features of MUD may be more common in females, while other features may be more common among individuals of African American versus White racial backgrounds. In addition, preliminary evidence indicates that MUD may be comorbid with depression, while some newer studies report on the existence of other comorbidities (e.g., ADHD, generalized anxiety disorder, and substance use disorders). Further research, including clinical trials, are necessary to examine these associations.
Ecological momentary intervention as a form of therapy appears to provide benefits for drug abuse and dependence treatment. Further research and randomized controlled trials with appropriate sample size are needed to examine the effectiveness of EcM-I specifically for the treatment of drug abuse and dependence.