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CFZ533 for Liver Transplant Rejection (CONTRAIL I Trial)
CONTRAIL I Trial Summary
This trial is testing a new drug to see if it's safe and effective in liver transplant patients, as well as how it is metabolized and affects the body.
CONTRAIL I Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2017 Phase 1 & 2 trial • 59 Patients • NCT02217410CONTRAIL I Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
Could I take part in this experiment if I meet the requirements?
"This clinical trial is admitting 132 patients, between the ages of 18 and 70 who have rejection; transplant, liver. It is important that participants also meet the following criteria: Screening period up to liver transplantation: -Written informed consent obtained before any assessment., Recipients of a primary liver transplant from a deceased donor., Up to date vaccination as per local immunization schedules., MELD score ≤30., Allograft is functioning at an acceptable level by the time of randomization as defined by AST, ALT, Alkaline Phosphatase levels ≤ 5 times ULN and Total bilirubin ≤ 2"
What are the conditions that CFZ533 can help treat?
"CFZ533 is most commonly used as an atopic dermatitis medication, but it can also be effective in treating transplant rejection (liver and kidney), as well as psoriasis."
Are there any serious dangers associated with taking CFZ533?
"CFZ533 has received a score of 2 in regards to safety. While there is Phase 2 trial data supporting its safety, there are no efficacy studies as of yet."
Could you tell me if CFZ533 has been explored in other research?
"There are a total of 153 clinical trials researching CFZ533, with 18 of them being in Phase 3. The largest concentration of these studies is located in Pennsylvania near Philadelphia; however, research is being conducted at 875 different locations worldwide."
How many people are being included in this experiment?
"This particular clinical trial is no longer recruiting patients. The initial posting was on October 7th, 2019 and the most recent update was on October 14th, 2020. There are 6 other trials currently admitting participants who have rejection; transplant, liver and 153 studies for CFZ533 that are also actively seeking patients."
Does this trial encompass patients who are over 20 years old?
"The age limit for enrolment in this study is 70 years old. All patients that meet this criteria and are above the age of 18 may participate."
Are there any available appointments for this study?
"This study is not taking any more participants at the moment. According to the information on clinicaltrials.gov, this trial was first posted on October 7th 2019 and was last updated on October 14th 2020. If you are looking for other studies, there are currently 6 trials related to rejection; transplant, liver and 153 trials for CFZ533 that are admitting patients right now."
In how many areas is this research being conducted?
"There are 12 sites currently enrolling patients for this study, which are located in cities such as Boston, Dallas and San Francisco. If you decide to participate in the trial, try to select a location close to minimize travel demands."
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