Treatment for Acute Traumatic Pain
Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain
See full descriptionAbout the trial for Acute Traumatic Pain
Treatment Groups
This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
Eligibility
This trial is for male patients aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Treatment will improve 1 primary outcome in patients with Acute Traumatic Pain. Measurement will happen over the course of between pre-treatment EMS assessment (baseline) and at 30-minutes post-treatment.
Patient Q & A Section
What are common treatments for acute traumatic pain?
Treatment of trauma often involves pain control and the administration of intravenous opioids. There is a need to create a comprehensive, standardised trauma system to ensure optimal clinical care is provided to patients suffering severe injury or severe pain. Clinicians need to be aware of the appropriateness of the use of medication and to be aware of any contraindications or side effects of the medications.
How many people get acute traumatic pain a year in the United States?
Approximately 1.7 million people in the US had a moderate-severe acute pain episode at one point in time in 2004. Half of these people were male and half were female. Most incidents (77%) were related to the injuries that result in death or disability. Preventive policies and management need to improve.
What is acute traumatic pain?
Acute traumatic pain is a multifactorial entity that is the consequence of acute traumatic injuries. It is caused by the activation of a complex pain-system network that comprises descending modulating pain systems, central sensitization, descending modulatory pathways, and diffuse peripheral pain networks. It is accompanied by a range of other multidimensional symptoms associated with acute traumatic pain. These include: acute emotional and behavioral changes, somatic sensory changes, and physical posttraumatic symptoms. Recent findings provides an outline of the pain-system network that may be activated in both acute and persistent posttraumatic pain and its clinical consequences.
What causes acute traumatic pain?
The present findings show that specific mechanisms contributing to acute traumatic pain should be investigated further in order to develop strategies to decrease the pain intensity, the time to reduce it, and prevent its occurrence in acutely painful conditions.
What are the signs of acute traumatic pain?
The most commonly reported acute traumatic pain signs are pain/shivering, increased heart rate, and decreased range of motion. This information will help physicians and caregivers identify the pain in the ED. The signs of acute traumatic pain are similar to those of other types of acute pain.
What are the latest developments in treatment for therapeutic use?
There are a few new therapies being developed to combat postoperative pain. They are based on advances in the understanding of the mechanisms of pain and pain signaling, with an aim at inhibiting or preventing the perception of pain signals. In addition, there are new ways of interfering with the neurobehavioral mechanisms and altering pain experience itself. While pain relief may be an effective treatment, there is no single most effective treatment for postoperative pain.
Have there been any new discoveries for treating acute traumatic pain?
Although many studies have not found any significant improvements for [pain management](https://www.withpower.com/clinical-trials/pain-management), there still remain some evidence that pain medication may help alleviate pain. For example, a study in 2018 found that low-dose [intrathecally delivered] meperidine significantly reduced post-injury pain and opioid requirement after ankle sprain.
What does treatment usually treat?
This treatment usually treats acute traumatic pain. The most common treatments prescribed for this condition were opioids, which were used to treat the acute pain. The most commonly listed treatments prescribed for chronic pain were opioid drugs, nonsteroidal anti-inflammatory drugs, physiotherapy, splints and nonsteroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs and exercise therapy. The first line treatment for chronic pain was opioid medicines.
What is the average age someone gets acute traumatic pain?
Median age of acute traumatic pain was 42 (range 17 to 89) years. There may be a relationship between age and severity of pain but it is not clear whether age is a cause or product of severity of acute traumatic pain.
How serious can acute traumatic pain be?
The majority of the patients reported pain on a 0-to-10 scale at the time of the survey. Half the respondents reported pain when their medical record was reviewed. More than two in ten reported that they had seen another doctor because of their medical condition. Physicians should be aware that most acutely injured trauma patients do not report pain.
Have there been other clinical trials involving treatment?
Given the importance of clinical trials in assessing treatments and developing treatment paradigms, this study highlights the utility of systematic research, highlighting both the need for additional clinical trials and the benefit of the public health approach that this entails. Results from a recent clinical trial reinforce the importance of public research spending in the development of treatments for a wide range of illnesses.