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Repetitive Transcranial Magnetic Stimulation

continuous Theta Burst Stimulation for Healthy Subjects

N/A
Waitlist Available
Led By Nolan Williams, M.D.
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Willingness to suspend use of analgesic drugs or cough suppressants for 24 hours prior to the scans
Right-handed
Timeline
Screening 3 weeks
Treatment Varies
Follow Up prior to and and immediately after tbs sessions on each day (separated by 3+ days)
Awards & highlights

Study Summary

This trial will use fMRI to study the effects of a new form of repetitive transcranial magnetic stimulation (rTMS), called theta burst stimulation (TBS), on the brain. TBS can be either excitatory (iTBS) or inhibitory (cTBS), and will be applied to the motor cortex. The goal is to see how TBS affects brain activity and behavior, and how long these effects last.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You must stop taking painkillers or cough medicine 24 hours before the scans.
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You must be right-handed.
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You are willing to undergo an fMRI scan.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~prior to and and immediately after tbs sessions on each day (separated by 3+ days)
This trial's timeline: 3 weeks for screening, Varies for treatment, and prior to and and immediately after tbs sessions on each day (separated by 3+ days) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Motor Evoked Potential
Secondary outcome measures
Change From Baseline Motor Cortex Activity as Assessed by the BOLD Signal Immediately Post-TBS
Change From Baseline Resting-state Functional Connectivity Between the M1 Hotspot and Other Motor Areas Immediately Post-TBS
Changes in Arterial Perfusion

Trial Design

2Treatment groups
Experimental Treatment
Group I: intermittent Theta Burst StimulationExperimental Treatment1 Intervention
The investigators will perform two applications of 40s of intermittent Theta Burst Stimulation (iTBS) form of rTMS at 80% resting motor threshold (previously determined), with a 15 minute intersession interval. The standardized treatment location for the left motor cortex will be determined by Localite Neuronavigation. The baseline structural scan obtained during the scan 1 will be utilized for this localization process.
Group II: continuous Theta Burst StimulationExperimental Treatment1 Intervention
The investigators will perform two applications of 40s of continuous Theta Burst Stimulation (cTBS) form of rTMS at 80% resting motor threshold (previously determined), with a 15 minute intersession interval. The standardized treatment location for the left motor cortex will be determined by Localite Neuronavigation. The baseline structural scan obtained during the scan 1 will be utilized for this localization process.

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,373 Previous Clinical Trials
17,327,925 Total Patients Enrolled
Nolan Williams, M.D.Principal InvestigatorStanford University
1 Previous Clinical Trials
101 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this trial actively seeking new participants?

"According to the information available on clinicaltrials.gov, this trial is currently taking in new patients. The initial posting was published April 1st 2019 and updated most recently on May 4th 2022."

Answered by AI

To what extent has patient participation been achieved in this clinical experiment?

"Affirmative. Information on clinicaltrials.gov reveals that this experiment is presently enrolling volunteers, having been first announced on April 1st 2019 and most recently revised on May 4th 2022. This endeavor requires 10 test individuals to be enrolled at one location."

Answered by AI

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
Stanford University
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
Recent research and studies
~6 spots leftby Mar 2025