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Combination Immunotherapy for Melanoma
Study Summary
This trial is testing a combination of therapies to treat melanoma- cryosurgery, dendritic cell therapy, and pembrolizumab.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I am currently on antibiotics for an infection.You have had a severe allergic reaction to the pneumococcal vaccine or any part of it in the past.You have a history of vitiligo or childhood asthma/atopy that is no longer active.My melanoma cannot be removed by surgery and is at an advanced stage.Your lymphocyte count should be at least 500 per cubic millimeter within 14 days before joining the study.Women who can have babies must have a negative pregnancy test within 7 days before joining the study.My underactive thyroid condition is stable with medication.Your platelet count is at least 100,000 per cubic millimeter and was checked within the last 14 days.Your hemoglobin level needs to be between 10 and 14 grams per deciliter within two weeks before joining the study.I haven't taken systemic steroids for more than 2 weeks, except for low-dose or non-systemic uses.My brain metastases are stable or improved for 90 days without steroids after treatment.I haven't had cancer treatment in the last 2 weeks or still have side effects.I have an autoimmune disease but haven't needed systemic treatment in the last 3 months.I use inhalers or get steroid shots occasionally.My diabetes is under control with my current treatment plan.My psoriasis can be managed without pills or injections.My cancer progressed or didn't respond to specific immune therapy after 18 weeks.I am fully active or restricted in physically strenuous activity but can do light work.I have at least two treatable tumors not previously treated with radiation, excluding the brain.My kidney function, measured by creatinine levels, is within the normal range.I do not have active tuberculosis or lung inflammation.Your total bilirubin level must be within a certain range, unless it's due to a specific condition called Gilbert's disease.Your liver enzyme levels are not more than 2.5 times the normal limit in the blood test taken within 14 days before joining the study.I have a history of HIV, hepatitis B, or hepatitis C.I have been diagnosed with interstitial lung disease.I have severe heart issues, including recent heart failure or heart attack.I haven't taken any experimental cancer treatments in the last 3 weeks.I haven't had cancer treatment except for skin cancer or cervical pre-cancer in the last 3 years.I still have mild side effects from previous immunotherapy, except for treated hormone issues.I have a condition where my adrenal glands don't produce enough hormones due to previous inflammation of the pituitary gland, and I am only on replacement therapy.I don't have blood clotting issues that prevent stopping blood thinners for a procedure.I have not received a live vaccine in the last 30 days.I have not had major surgery in the last 4 weeks.You must have at least 3 visible lesions on a radiographic image.You have had a positive Coombs test in the past, but no signs of blood cell breakdown.My white blood cell count is healthy.I have at least one tumor that can be measured and hasn't been treated with radiation.Medical conditions that are not likely to happen again unless something outside the body causes them.
- Group 1: Treatment (apheresis, pembrolizumab, cryosurgery, mDCs)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
For what reasons is Cryosurgery most commonly used?
"Cryosurgery can be used to treat cancerous growths, inoperable melanoma, and microsatellite instability."
Are we currently enrolling patients in this trial?
"This specific study, whose first posting was on November 15th 2017, is not looking for new patients at this time according to clinicaltrials.gov. Although, there are 1848 other trials which ARE recruiting individuals right now."
Does this treatment have a history?
"There are currently 1000 active clinical studies being conducted on cryosurgery, with 122 of those in the third and final phase. The majority of these trials originate from Houston, Texas; however, there are 36030 locations running similar studies."
What is the upper limit for how many people can join this experiment?
"As of right now, this particular trial is not looking for any more participants. This information is based off the study's posting date (11/15/2017) as well as its last update (10/25/2022). For those still searching for trials to join, there are 848 clinical trials actively recruiting patients with stage iv cutaneous melanoma ajcc v6 and v7 and 1000 studies for Cryosurgery that need participants."
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