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XXB750 for Resistant Hypertension
Study Summary
This trial tests different doses of a new drug for resistant hypertension. It compares them to a placebo and evaluates safety, effectiveness and how well it's tolerated.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- Your upper arm is bigger than 44 centimeters.I am taking more than 4 medications for high blood pressure.I have Type I diabetes or my Type II diabetes is not under control (HbA1c ≥9%).My kidney function is low, with a GFR under 30 mL/min.I have undergone a procedure to treat high blood pressure affecting my kidneys.I am 18 years old or older.I don't regularly use NSAIDs, except for low-dose aspirin up to 325 mg daily.My average blood pressure is 135 mmHg or higher, despite taking the highest dose of blood pressure medication I can tolerate.My blood pressure is high despite taking three or four different blood pressure medications.I have liver disease.I haven't had serious heart rhythm problems in the last 6 months.People who work at night.I have been hospitalized for severe high blood pressure crises.I have had a heart problem in the last year.I am a woman who can have children and am not using strong birth control methods.I have high blood pressure due to another health condition.I do not have any other diseases that would limit my life to under 3 years.Your blood pressure is lower than 140 mmHg at Visit 20.Your blood pressure is very high during the visit before starting the study.Your average blood pressure is too high when measured over a 24-hour period.I have not had cancer in any part of my body in the last 3 years.I struggle to understand or follow instructions.You have a history of using drugs or being dependent on alcohol.Your blood test shows that you have too much potassium in your blood.I am currently on or have recently taken medication for heart failure.
- Group 1: Dose 4
- Group 2: Dose 1
- Group 3: Dose 5
- Group 4: Dose 2
- Group 5: Dose 3
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What security measures have been implemented to ensure the safety of participants receiving Dose 3?
"Our analysts have evaluated the safety of Dose 3 as a 2, since it is in Phase 2 trials and has evidence for its security but not its effectiveness."
Are there any openings to join the trial at this time?
"Affirmative, according to clinicaltrials.gov the trial is presently recruiting patients; with its initial posting date on November 8th 2022 and last edited two weeks later. An estimated 170 participants are sought from 3 distinct medical sites."
What is the size of the patient population involved in this clinical investigation?
"Affirmative. Data hosted on clinicaltrials.gov verifies that this medical investigation, which was inaugurated on November 8th 2022, is seeking patient participation. Approximately 170 individuals need to be enlisted from 3 separate research centres."
Who else is applying?
What site did they apply to?
What portion of applicants met pre-screening criteria?
What questions have other patients asked about this trial?
Why did patients apply to this trial?
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