This trial is evaluating whether Uproleselan will improve 2 primary outcomes and 13 secondary outcomes in patients with Neoplasm Metastasis. Measurement will happen over the course of From date of CR/CRi to date of disease relapse, death or last follow-up, whichever occurred first, assessed up to 4.5 years.
This trial requires 37 total participants across 1 different treatment group
This trial involves a single treatment. Uproleselan is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"Leukemia, myeloid, acute is a type of blood cancer.\nLeukemia is a group of blood cancer that starts in the bone marrow. Different kinds of leukemia have different types of symptoms which might include a continuous feeling of tiredness, feeling hot, feeling fatigued, feeling a lot of thirst and the feeling of tiredness and being fainter might happen.\nMeadowdale Hospital (now known as Meadowvale Hospital) was the first hospital in New Zealand for patients with leukaemia and it is located in the suburb of Meadowvale. In the early-1950s, the institution in Meadowvale became the first public hospital in New Zealand to use antibiotics to treat its patients." - Anonymous Online Contributor
"AML/MDS are not curable. At present, there are no cures for AML, which is a highly lethal disease. Long-term studies are necessary to better understand leukemogenesis in order to develop new therapies, including gene therapy. Results from a recent paper of future treatment are unlikely to be known by this criterion." - Anonymous Online Contributor
"Between 4 and 8 people per year get leukemia, myeloid, acute. This is comparable to the mortality (2.1 per year, 5-11 per 100,000 population) and incidence (6.3 per 100 million population) of leukemia. The incidence of myeloid leukemia is 1.7 times the incidence of leukemia, irrespective of demographic subgroups." - Anonymous Online Contributor
"Some non-randomized trials suggest that aspirin is ineffective in people with acute leukemias; however, randomized trials are not available that compare aspirin to current standard management for acute leukemias. There are no randomized trials comparing aspirin-containing chemotherapy regimens to active chemotherapy for acute myeloid leukemia. No randomized trials support the use of statins for people with acute myeloid leukemia." - Anonymous Online Contributor
"Families with leukemia have a family history of leukemia more than 2 years before the first case. Therefore, an individualized clinical evaluation is needed in familial cases of AML." - Anonymous Online Contributor
"About 38.3% of people who get leukemia (or myeloid, acute) will be more than 49 years of age. In general, leukemia patients who are more than 47 years have good survival chances compared to patients less than 47 years of age. Older patients generally have good survival.\n\nA common cancer to come across is Non-Hodgkin’s Tumor or NHT (T-L). They are a group of cancers that are formed by white blood cells rather than non-purple blood cells." - Anonymous Online Contributor
"The common side effects seem to be similar in leukemic and nonleukemic populations treated with lenalidomide, but the patients with myelogenous leukemia appear to run a higher risk of side effects." - Anonymous Online Contributor
"The majority of patients eligible for clinical trials were not eligible based on eligibility criteria. Clinical trials for Leukemia, Myeloid Acute, are often used both to enroll new patients and for data-collection purposes for patients already in the treatment process." - Anonymous Online Contributor
"The study results corroborate the hypothesis of a new melanocortin-related peptide. On the other hand, these peptides, which are under preliminary investigation, could possibly be mediators of tumor growth. Findings from a recent study clearly show that melanocortins need to be evaluated further in patients with myeloid diseases." - Anonymous Online Contributor
"The study has confirmed that uproleselan (in combination with duloxetine hydrochloride) is more effective than a placebo against pain relief induced by oral administration of morphine. Neither uproleselan nor duloxetine hydrochloride was more effective than a placebo when given alone as analgesics. Uroplus was associated with more nausea and VOM." - Anonymous Online Contributor