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Hormone Therapy
High-Dose Megestrol for Advanced Cancers
Phase 1 & 2
Waitlist Available
Research Sponsored by St. Vincent Medical Center - Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Indicator lesions other than blastic bony metastases and pleural effusions required for breast cancer
Age: At least 18
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial will study the effectiveness of high-dose megestrol in treating patients with metastatic breast cancer, endometrial cancer, or mesothelioma.
Who is the study for?
This trial is for adults with metastatic breast, endometrial cancer, or mesothelioma that can't be removed by surgery or controlled with radiation. Participants must have a life expectancy of at least 3 months and measurable cancer lesions. Women with breast cancer should have hormone-receptor-positive tumors.Check my eligibility
What is being tested?
The study is testing high doses of the hormone therapy drug megestrol to see if it can slow down or stop the growth of certain cancers by reducing hormone production. This phase I/II trial aims to determine its effectiveness in advanced cases.See study design
What are the potential side effects?
Megestrol may cause weight gain, increased appetite, fluid retention, upset stomach, and potential hormonal changes such as hot flashes or mood swings.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My breast cancer has spread, but not to my bones or causing fluid around my lungs.
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I am 18 years old or older.
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My cancer is positive for estrogen and/or progesterone receptors.
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My cancer cannot be cured or controlled long-term with surgery or radiation.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
St. Vincent Medical Center - Los AngelesLead Sponsor
3 Previous Clinical Trials
40 Total Patients Enrolled
Charles L. Wiseman, MD, FACPStudy Chair
4 Previous Clinical Trials
64 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My cancer cannot be cured or controlled long-term with surgery or radiation.My breast cancer has spread, but not to my bones or causing fluid around my lungs.It has been over 4 weeks since my last biologic therapy.I have cancer that can be measured by scans.I am 18 years old or older.It has been over 4 weeks since my last radiotherapy session.My breast cancer is positive for estrogen and/or progesterone receptors.My breast cancer has spread, but not to my bones or causing fluid around my lungs.My breast cancer hasn't worsened after hormone therapy, or I've just finished hormone therapy for another cancer.It has been at least 4 weeks since my last surgery.My cancer is positive for estrogen and/or progesterone receptors.My cancer cannot be cured or controlled long-term with surgery or radiation.It has been over 4 weeks since my last chemotherapy session.You are expected to live for at least 3 more months.Your menopausal status does not affect your eligibility.My physical condition has not been assessed yet.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the research team currently recruiting participants?
"The listing on clinicaltrials.gov expresses that this investigation is no longer enrolling patients, having first been posted in December 1987 and last amended in November 2013. That being said, there are a substantial number of other studies actively looking for volunteers at present.; 2964 to be exact."
Answered by AI
Who else is applying?
What site did they apply to?
St. Vincent Medical Center - Los Angeles
What portion of applicants met pre-screening criteria?
Met criteria
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