Search > Age-Related Macular Degeneration
My employer runs this trial

EYC-0305 for Age-Related Macular Degeneration

(OVERTURE Trial)

Not yet recruiting at 4 trial locations
EI
Overseen ByEyconis, Inc.
Age: 18+
Sex: Any
Trial Phase: Phase 1 & 2
Sponsor: Eyconis INC.
Disqualifiers: Uncontrolled diabetes, CVA, renal failure, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This Phase 1b/2a study will primarily investigate the safety and tolerability of EYC-0305 delivered by intravitreal (IVT) injection every 24 weeks in patients with neovascular (wet) age-related macular degeneration (AMD). The pharmacokinetics (PK) and immunogenicity of EYC-0305, and the effect on disease activity and vision will also be evaluated.

Are You a Good Fit for This Trial?

This trial is for men and women aged 50 or older who have neovascular (wet) age-related macular degeneration. Participants must be able to attend clinic visits, follow study procedures, and give informed consent.

Inclusion Criteria

I am willing and able to attend clinic visits and follow study procedures.
I have signed the informed consent form.
I am 50 or older and have wet age-related macular degeneration.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive intravitreal (IVT) injections of EYC-0305 every 24 weeks to assess safety, tolerability, pharmacokinetics, and immunogenicity.

24 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment, including effects on disease activity and vision.

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • EYC-0305

Trial Overview

The study is testing the safety of EYC-0305, given as an injection into the eye every 24 weeks, in people with wet AMD. Researchers will also look at how the drug moves through the body and its effects on vision.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Group I: EYC-0305 Dose Level 4Experimental Treatment1 Intervention
Group II: EYC-0305 Dose Level 3Experimental Treatment1 Intervention
Group III: EYC-0305 Dose Level 2Experimental Treatment1 Intervention
Group IV: EYC-0305 Dose Level 1Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Eyconis INC.

Lead Sponsor

Unbiased Results

We believe in providing patients with all the options.

Your Data Stays Your Data

We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.