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Ixazomib + Rituximab for Mantle Cell Lymphoma
Study Summary
This trial is testing ixazomib given with rituximab after stem cell transplant to see how well it works and what the side effects are.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I haven't had radiotherapy in the last 14 days, or if it was a small area, in the last 7 days.I haven't needed IV antibiotics or had a serious infection in the last 14 days.I am not pregnant or breastfeeding.I am a male and agree to follow the birth control requirements.I don't have GI issues that affect medicine absorption or swallowing.My heart condition has been stable for at least 60 days.I do not have an active infection, including hepatitis B or C, or HIV.I have severe nerve damage in my hands or feet, or moderate with pain.I haven't been on any other clinical trials for 30 days.I have not relapsed or worsened since starting my initial cancer treatment.I am surgically sterile.I can start treatment between day 70 and 180, depending on my blood test results.I haven't had cancer, except for certain skin, cervical, or low-risk prostate cancers, in the last 2 years.I agree to practice true abstinence as a form of contraception.My cancer has a specific genetic feature known as t(11;14).My blood tests show enough neutrophils and platelets, and I haven't had a platelet transfusion in the last 3 days.I have been postmenopausal for at least one year.I have mostly recovered from my last chemotherapy, with only minor side effects remaining.I have not been treated with ixazomib, but I may have received bortezomib.My kidneys are functioning well enough, with a creatinine clearance rate of at least 30 mL/min.My cancer cells show cyclin D1 presence.I have had lymphoma in my brain or spinal cord but no active disease after initial treatment.I completed a stem cell transplant after my first cancer treatment without relapsing before the transplant.I agree to practice true abstinence as a form of contraception.I haven't taken specific strong medications or St. John's wort in the last 14 days.My diagnosis of mantle cell lymphoma has been confirmed.My condition hasn't worsened since my transplant.I am a female patient.I have not had major surgery in the last 14 days.I can take care of myself and am up and about more than half of my waking hours.
- Group 1: Treatment (ixazomib, rituximab)
Frequently Asked Questions
What medical conditions can Rituximab be utilized to mitigate?
"Rituximab is a popular therapeutic treatment for diffuse large b-cell lymphoma (dlbcl) and can also be utilized to manage other conditions such as polyangium, pemphigus vulgaris, and multiple different types of B-Cell lymphomas."
How many individuals are involved in this experiment?
"As it stands, this clinical trial is not accepting participants. Its initial posting dates back to March 1st 2016 and its last edit was made on October 26th 2021. If you are searching for new opportunities, there are currently 1720 distinct trials related to lymphoma, mantle-cell seeking enrolment as well as 471 Rituximab trials actively recruiting patients."
Are there currently any vacancies available in this clinical research project?
"As per the clinicaltrials.gov database, it appears that this medical trial is not accepting participants at this time. The first posting of the study was on March 1st 2016 and most recently updated on October 26th 2021. Unfortunately, no more applicants are being accepted for enrollment; however, there are 2191 other trials actively searching for patients as we speak."
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