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Anti-hypertensive

ION904 for High Blood Pressure

Phase 2
Waitlist Available
Research Sponsored by Ionis Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Males must be surgically sterile or, abstinent or, if engaged in sexual relations with a woman of child-bearing potential (WOCBP), she uses a highly effective contraceptive method.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to approximately 15 weeks
Awards & highlights

Study Summary

This trial will test a new drug for hypertension (high blood pressure). It will see if the drug lowers AGT levels in the blood.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to approximately 15 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to approximately 15 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent Change from Baseline in Plasma Angiotensinogen (AGT)
Secondary outcome measures
Change from Baseline in Seated Automated Office Diastolic Blood Pressure (DBP)
Change from Baseline in Seated Automated Office Systolic Blood Pressure (SBP)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ION904Experimental Treatment1 Intervention
Up to 4 monthly doses of ION904 will be administered by subcutaneous (SC) injection.
Group II: PlaceboPlacebo Group1 Intervention
Up to 4 monthly doses of placebo will be administered by SC injection.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ION904
2022
Completed Phase 2
~90

Find a Location

Who is running the clinical trial?

Ionis Pharmaceuticals, Inc.Lead Sponsor
145 Previous Clinical Trials
15,217 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can new participants sign up for this experiment?

"According to the listing on clinicaltrials.gov, this trial is not presently enrolling patients. This particular study was first announced on April 26th, 2022 and has since been updated on August 31st, 2022. Although this research is not taking any new participants at the moment, there are 785 other trials that are currently recruiting individuals."

Answered by AI

Are there any age restrictions for participants in this trial?

"The age range for this trial is between 18 and 75. There are 56 other trials available to people under the legal age of consent and 694 different studies for patients over 65."

Answered by AI

Are there other research facilities in the state conducting this investigation?

"There are 11 enrolling sites for this study, which are listed below. - National Research Institute in Los Angeles, California - Progressive Medical Research in Port Orange, Kansas - Altasciences in Overland Park, New york"

Answered by AI

How can I sign up to take part in this research project?

"This clinical trial has 48 available spots for patients that fit the following profile: hypertensive, between 18-75 years old, history of uncontrolled hypertension despite medication, no changes to antihypertensive regimen in the 4 weeks before screening, BMI ≤ 45.0 kg/m^2, and must be able to maintain study requirements throughout the treatment period. Males must either be surgically sterile or abstinent; if they are sexually active with a woman of childbearing potential, she must use an effective method of contraception."

Answered by AI

What is ION904's standing with the FDA?

"ION904 is still in Phase 2 clinical trials, so there is not yet sufficient data to confirm its efficacy. However, the safety profile of ION904 appears promising as it has cleared multiple rounds of testing."

Answered by AI

Who else is applying?

What state do they live in?
California
How old are they?
65+
What site did they apply to?
Clinical Trials Research
What portion of applicants met pre-screening criteria?
Met criteria
~17 spots leftby Mar 2025