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Radiation Therapy

Post-Surgery Radiation Therapy for Head and Neck Cancer

Phase 1 & 2
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 and over
Reirradiation field must overlap the previous field for a minimum of 3 cm in height, width, and length
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is to study if radiation therapy is effective in treating patients with recurrent or second primary cancer of the head and neck who have had previous radiation therapy.

Who is the study for?
This trial is for adults who've had surgery for a recurrent or second primary head and neck cancer after previous radiation. They must have had prior radiation with significant overlap to the current area, be at least 6 months post-prior radiation, and have certain types of squamous cell carcinoma with specific conditions like positive margins or nodes.Check my eligibility
What is being tested?
The study is examining the effectiveness of additional radiation therapy following surgery in patients who previously received radiation for head and neck cancers. It's designed to see if more radiation can help prevent cancer from coming back.See study design
What are the potential side effects?
Potential side effects include damage to skin, subcutaneous tissue, larynx, joints; severe reactions in mucous membranes or bones due to increased exposure to high-energy x-rays on top of previous treatments.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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My new radiation treatment area overlaps with the old one by at least 3 cm in all directions.
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I have not experienced severe side effects in my organs.
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I have no cancer history likely to cause death within 3 years.
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I can care for myself but may not be able to do active work.
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My cancer has spread beyond its original location.
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My cancer is a type of squamous cell carcinoma that has come back or is a new cancer in certain areas.
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All visible signs of my cancer were surgically removed.
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It has been over 6 months since my last radiotherapy with a high dose.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,571 Previous Clinical Trials
2,269,411 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,627 Previous Clinical Trials
40,927,341 Total Patients Enrolled
James L. Pearlman, MDStudy ChairH. Lee Moffitt Cancer Center and Research Institute
2 Previous Clinical Trials
6 Total Patients Enrolled

Media Library

Radiation Therapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT00004226 — Phase 1 & 2
Head and Neck Cancers Research Study Groups:
Head and Neck Cancers Clinical Trial 2023: Radiation Therapy Highlights & Side Effects. Trial Name: NCT00004226 — Phase 1 & 2
Radiation Therapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00004226 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants being accepted into this clinical trial?

"No, this particular clinical trial is not recruiting patients at the moment. This can be confirmed by checking the posting dates on clinicaltrials.gov; the study was first posted on 5/1/2000 and last updated on 12/3/2013. However, there are 499 other trials which are actively looking for patients right now."

Answered by AI
~14 spots leftby Mar 2025