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MK-3475 + MRI-guided Laser Ablation for Brain Tumor
Study Summary
This trial is testing whether a combination of two treatments can better control brain tumors than either treatment alone. MLA is a type of surgery that uses lasers to target and destroy tumors. MK-3475 is a drug that helps the immune system better recognize and attack tumors.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- I need blood thinners but can stop them for surgery or use a filter instead.My brain tumor was treated with surgery, radiation, and chemotherapy.I have been diagnosed with a grade IV brain tumor (GBM).I am a candidate for a specific brain tumor treatment as decided by my neurosurgeon.I have an immune system disorder or have been on steroids or other immune-weakening medicines in the last week.I have been diagnosed with a grade IV brain tumor (GBM).My surgeon says I'm a good candidate for a specific brain surgery based on my tumor's characteristics.I had surgery to remove as much of the tumor as possible at least 3 weeks before starting MK-3475.I had surgery to remove a cancer recurrence.My cancer has shown clear growth on recent scans or biopsies.My blood tests for bone marrow and organ function are normal.I do not have any unmanaged ongoing illnesses.My condition is either a GBM variant or suspected secondary GBM.I agree to use contraception during and for 4 months after the study.I had surgery to remove a recurring tumor and may receive treatment to target the area around the surgery site.My brain tumor is confirmed to be high-grade (grade III or IV).My grade III brain tumor was treated with surgery, radiation, and chemotherapy.My grade III brain tumor was treated with surgery, radiation, and chemo, but it came back.I haven't had monoclonal antibody treatment in the last 4 weeks or still have side effects from treatments over 4 weeks ago.I haven't had a brain bleed in the last 8 weeks, unless it's where my tumor will be treated.I have an active tuberculosis infection.I have been diagnosed with HIV.It's been over 12 weeks since my last standard treatment, or my cancer has clearly returned.You have had an allergic reaction to drugs similar to MK-3475, or any other drugs being used in the study.I am not currently in any other clinical trials or have been in one within the last 3 weeks.I have been treated for an autoimmune disease in the last 2 years.I have brain lesions near critical areas.You are currently pregnant or breastfeeding.My cancer has clearly worsened, as shown by recent tests.I am 18 years old or older.My cancer has spread to the lining of my brain and spinal cord.I have had lung inflammation that needed steroids or have it now.I have been treated with specific immune therapy drugs before.I am taking more than 4 mg of dexamethasone.My brain cancer affects both sides and has multiple tumors.I have had treatment on the area where the new treatment is planned.I have not received a live vaccine in the last 30 days.I haven't had chemotherapy, targeted therapy, or radiation in the last 2 weeks.I am a candidate for surgery aimed at curing my condition.I have a history of hepatitis B or currently have hepatitis C.My diagnosis includes GBM or its variants.I have previously been treated with medication to stop the formation of new blood vessels in cancer.My brain tumor is confirmed to be high-grade (grade III or IV).I am mostly able to care for myself but may need occasional help.I am 18 years old or older.
- Group 1: Phase I: MK-3475 + MLA
- Group 2: Phase II: MK-3475 Only (Arm B)
- Group 3: Phase II: MK-3475 + MLA (Arm A)
- Group 4: Phase II (after amendment #12): MK-3475 + MLA
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this type of surgery have a precedent?
"City of Hope conducted the first clinical trial for MRI-guided laser ablation in 2010 and, since then, there have been 286 completed trials. As of now, there are 1000 active trials taking place with several hospitals in Saint Louis, Missouri."
What types of conditions does MRI-guided laser ablation target?
"While most commonly used to treat malignant neoplasms, MRI-guided laser ablation can also be an effective treatment for certain conditions like microsatellite instability high and disease progression after chemotherapy."
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