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Vasodilator

Nitric Oxide for COPD (iNO Trial)

Phase 1 & 2
Waitlist Available
Led By Michael K Stickland, PhD
Research Sponsored by University of Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No significant neuromuscular disease
Minimal smoking history
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed every 2-minutes until completion of the exercise trial; anticipating ~10-14 minute tests
Awards & highlights

iNO Trial Summary

This trial is testing whether inhaled nitric oxide can help people with COPD exercise without feeling as breathless.

iNO Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You do not have any major nerve or muscle disorders.
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You have not smoked very much in your life.
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You don't have any major heart problems.
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You do not have any major metabolic diseases.

iNO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed every 2-minutes until completion of the exercise trial; anticipating ~10-14 minute tests
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed every 2-minutes until completion of the exercise trial; anticipating ~10-14 minute tests for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak Oxygen Consumption
Peak Workload
Secondary outcome measures
Dyspnea (breathlessness)
Emphysema severity score
Pulmonary artery systolic pressure

iNO Trial Design

2Treatment groups
Experimental Treatment
Group I: Control GroupExperimental Treatment2 Interventions
Control group to receive either placebo or inhaled nitric oxide (40ppm)
Group II: COPD GroupExperimental Treatment2 Interventions
COPD to receive either placebo or inhaled nitric oxide (40ppm)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitric Oxide
2004
Completed Phase 4
~1280
Placebo
1995
Completed Phase 3
~2670

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University Hospital FoundationOTHER
7 Previous Clinical Trials
1,246 Total Patients Enrolled
Canadian Lung AssociationIndustry Sponsor
9 Previous Clinical Trials
65,525 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,336 Previous Clinical Trials
25,750,968 Total Patients Enrolled

Media Library

Nitric Oxide (Vasodilator) Clinical Trial Eligibility Overview. Trial Name: NCT03679312 — Phase 1 & 2
Shortness of Breath Research Study Groups: COPD Group, Control Group
Shortness of Breath Clinical Trial 2023: Nitric Oxide Highlights & Side Effects. Trial Name: NCT03679312 — Phase 1 & 2
Nitric Oxide (Vasodilator) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03679312 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research pertain to individuals below a certain age?

"The age range that is able to enroll in this clinical trial as patients starts at 18 and caps at 85."

Answered by AI

What other medical studies have used Nitric Oxide as a variable?

"Currently, there are 24 clinical trials researching the effects of Nitric Oxide with 9 in Phase 3. Many of these studies originate from Alaskan medical centres in Anchorage, but investigations are being conducted globally at 116 different locations."

Answered by AI

How many people have been recruited for this experiment?

"That is correct, the information available suggests that this study is still looking for patients. The listing was posted on September 4th, 2018 and updated last on September 19th, 2022. They are aiming to recruit 140 people total from 1 site."

Answered by AI

Are there any available positions for test subjects in this clinical trial?

"This clinical trial, as indicated on the website clinicaltrials.gov, is looking for participants. The study was originally put up on September 4th 2018 and was edited most recently on September 19th 2022."

Answered by AI

How can I sign up to help with this research study?

"As this is a clinical study, those with dyspnea and who are between 18-85 years old may qualify to participate. Around 140 individuals will be admitted in total."

Answered by AI
~22 spots leftby Mar 2025