This trial is testing if mirdametinib is a safe treatment for people with advanced solid tumor cancer that has certain mutations.
- MEK1 Gene Mutation
- Breast Cancer
- MEK2 Gene Mutation
- Breast Cancer Stage IV
- Solid Cancer
- Metastatic Breast Cancer
- HER2-negative Breast Cancer
1 Primary · 0 Secondary · Reporting Duration: 28 days from first day of treatment
Side Effects for
Awards & Highlights
4 Treatment Groups
Arm 1, Part 1 - mirdametinib in combination with fulvestrant
1 of 4
Arm 1, Part 2 - mirdametinib in combination with fulvestrant
1 of 4
Arm 2, Part 1 - mirdametinib as single agent
1 of 4
Arm 2, Part 2 - mirdametinib as single agent
1 of 4
150 Total Participants · 4 Treatment Groups
Primary Treatment: Mirdametinib · No Placebo Group · Phase 1 & 2
Who is running the clinical trial?
Age 18+ · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
Are there other research papers that mention Mirdametinib?
"Mirdametinib was first studied in the year 2004 at Lowell General Hospital. To date there are a total of 89 completed clinical trials with 140 more currently underway. There is significant research being conducted out of Harrison, New York." - Anonymous Online Contributor
Is this study also taking place in other hospitals throughout Canada?
"There are 6 locations where this clinical trial is being conducted; these include Harrison, Commack and New York. If you decide to participate in this study, the investigators will work with you to select a site that is close to your home to minimize travel burden." - Anonymous Online Contributor
Are volunteers being sought for this clinical trial at the moment?
"The information available on clinicaltrials.gov supports that this trial is ongoing and looking for new participants. This particular study was first publicized on September 14th, 2021 with the most recent update being from September 13th, 2022. They are aiming to have 150 people enrolled from 6 different locations." - Anonymous Online Contributor
How many men and women are enrolled in this research project?
"That is correct, the clinicaltrials.gov website does show that this trial is open for recruitment. The listing shows that the study was first posted on September 14th, 2021 and was last updated on September 13th, 2022. They are looking for a total of 150 participants across 6 different sites." - Anonymous Online Contributor
What are the primary indications for Mirdametinib?
"Mirdametinib, while commonly used to treat endocrine conditions, can also be effective in treating other diseases such as breast cancer and those with a pik3ca gene mutation." - Anonymous Online Contributor