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High-Intensity Aerobic Exercise for Parkinson's Disease

Phase 2 & 3
Waitlist Available
Led By Jay L Alberts, PhD
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Hoehn and Yahr stage I-III
Demonstrate the ability to safely mount and dismount the Peloton stationary cycle
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (on and off medications), 6 months (off medications), 12 months (off medication)
Awards & highlights

Study Summary

This trial is examining whether a long-term, high-intensity aerobic exercise intervention can help to slow the progression of Parkinson's disease.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You have mild to moderate symptoms of Parkinson's disease.
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You can safely get on and off the Peloton stationary bike.
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You need to have a WiFi network at home to transmit exercise data through the Peloton system.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (on and off medications), 6 months (off medications), 12 months (off medication)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (on and off medications), 6 months (off medications), 12 months (off medication) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
MDS-UPDRS III Motor Score
Secondary outcome measures
Nine Hole Peg Test
Other outcome measures
Processing Speed Test

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: High-Intensity Exercise GroupExperimental Treatment1 Intervention
Mild to moderate Parkinson's disease patients: The exercise group will be asked to cycle 3x/week for 12 months on a Peloton bicycle which will be delivered to their home.
Group II: Usual and Customary Care GroupActive Control1 Intervention
Mild to moderate Parkinson's disease patients, receiving no exercise intervention through the research. They will continue to receive usual and customary care for their Parkinson's disease during the 12 month period.

Find a Location

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
1,020 Previous Clinical Trials
1,365,422 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,682 Previous Clinical Trials
6,930,542 Total Patients Enrolled
Jay L Alberts, PhDPrincipal InvestigatorThe Cleveland Clinic
1 Previous Clinical Trials
20 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are we able to enroll new patients at this time?

"The clinical trial in question, which was first posted on November 13th, 2019, is not currently recruiting patients according to the data on clinicaltrials.gov. The most recent update to the posting was on May 4th, 2022. There are 507 other trials that are actively recruiting patients."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
Pennsylvania
California
How old are they?
18 - 65
65+
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
~48 spots leftby Mar 2025