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Astaxanthin for Osteoarthritis

Phase 2 & 3
Waitlist Available
Led By Daniel Del Gaizo, MD
Research Sponsored by Prisma Health-Midlands
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Knee pain
Scheduled to undergo a total knee replacement
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Study Summary

This trial will study whether astaxanthin, a substance found in many aquatic animals, can help reduce inflammation, pain, and improve physical function in patients with advanced knee osteoarthritis.

Eligible Conditions
  • Arthritis
  • Osteoarthritis

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You experience pain in your knee.
Select...
You have a planned total knee replacement surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Effect of astaxanthin on inflammatory synovial markers in patients with osteoarthritis who are scheduled to undergo a total knee replacement surgery.
Secondary outcome measures
Effect of astaxanthin on PROMIS Pain Interference scores in patients with osteoarthritis who are scheduled to undergo a total knee replacement surgery.
Effect of astaxanthin on PROMIS Physical Function scores in patients with osteoarthritis who are scheduled to undergo a total knee replacement surgery.

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Experimental: Astaxanthin Supplementation GroupActive Control1 Intervention
Patients will receive a 6 week daily oral supply of 12 mg astaxanthin supplement.
Group II: Control: Placebo GroupPlacebo Group1 Intervention
Patients will receive a 6 week daily oral supply of placebo, identical in appearance to the astaxanthin supplement.

Find a Location

Who is running the clinical trial?

Prisma Health-MidlandsLead Sponsor
23 Previous Clinical Trials
2,810 Total Patients Enrolled
Daniel Del Gaizo, MDPrincipal InvestigatorPrisma Health-Midlands
1 Previous Clinical Trials
234 Total Patients Enrolled

Media Library

Experimental: Astaxanthin Supplementation Group Clinical Trial Eligibility Overview. Trial Name: NCT05138549 — Phase 2 & 3
Arthritis Research Study Groups: Control: Placebo Group, Experimental: Astaxanthin Supplementation Group
Arthritis Clinical Trial 2023: Experimental: Astaxanthin Supplementation Group Highlights & Side Effects. Trial Name: NCT05138549 — Phase 2 & 3
Experimental: Astaxanthin Supplementation Group 2023 Treatment Timeline for Medical Study. Trial Name: NCT05138549 — Phase 2 & 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are taking part in this experiment?

"Unfortunately, this study is no longer recruiting patients. The listing for the trial was created on September 2nd, 20222 and was last updated a month later on September 27th. If you are interested in other studies, please note that there are 1,408 trials currently looking for individuals with osteoarthritis and 14 trials enrolling participants for an "Experimental: Astaxanthin Supplementation Group.""

Answered by AI

Are there any prerequisites for participation in this experiment?

"To qualify for this study, patients must be aged 18-99 and currently suffer from osteoarthritis in the knee(s). In addition, all potential participants must meet the following requirements: ≥ 18 years of age, Knee pain."

Answered by AI

Can new patients still join the clinical trial?

"This study is no longer looking for patients as of September 27th, 2022. It was initially posted on September 2nd of the same year. If you are interested in other osteoarthritis trials, 1408 studies are currently recruiting and 1 trial specifically for those taking astaxanthin is also underway."

Answered by AI

Would this program be open to patients who are over 30 years old?

"According to the eligibility requirements specified by the clinical trial, patients must be aged between 18-99. Out of the 1244 total studies, 114 are for those under 18 and 1230 are for people 65 and older."

Answered by AI

Are there other instances where astaxanthin has been used in a similar capacity?

"One clinical trial in Phase 3 is ongoing for the Experimental: Astaxanthin Supplementation Group. Most of the research locations are out of Columbia, South carolina, but 1 study site remains."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Recent research and studies
~6 spots leftby Mar 2025