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Antibiotic
Doxycycline for Cardiac Amyloidosis
Phase 2 & 3
Waitlist Available
Research Sponsored by IRCCS Policlinico S. Matteo
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age ≥ 18.
Newly-diagnosed AL amyloidosis.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
Study Summary
This trial is testing whether doxycycline, a commonly used antibiotic, can improve survival in patients with a rare disease where abnormal proteins deposit in bodily organs and severely impair their function.
Eligible Conditions
- Cardiac Amyloidosis
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
proportion surviving
Side effects data
From 2021 Phase 4 trial • 26 Patients • NCT041670854%
Sinus infection
4%
Foot infection
4%
Metastatic lung cancer dx
4%
Blurred vision
4%
Emesis
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Doxycycline
Placebo
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Experimental interventionExperimental Treatment1 Intervention
doxycycline (100 mg bid)
Group II: Control interventionActive Control1 Intervention
Standard of care therapy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
2008
Completed Phase 4
~2430
Find a Location
Who is running the clinical trial?
IRCCS Policlinico S. MatteoLead Sponsor
119 Previous Clinical Trials
105,289 Total Patients Enrolled
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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