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Inspiratory Muscle Training for Respiratory Muscles Performance

N/A
Recruiting
Led By Richard E Moon, MD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
≥30 mL.kg-1.min-1 (females)
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 weeks
Awards & highlights

Study Summary

This trial will test whether training the muscles used for inspiration can increase a person's endurance while diving, and whether breathing in low concentrations of carbon monoxide can improve the performance of these muscles.

Who is the study for?
This trial is for non-smoking, healthy volunteers with good exercise capacity (VO2peak above certain levels) and a range of responses to high CO2 levels. Pregnant individuals, those with anemia or blood disorders like sickle cell, heart/lung diseases, or neuromuscular conditions cannot participate.Check my eligibility
What is being tested?
The study aims to see if training the breathing muscles while inhaling low-level carbon monoxide improves divers' underwater endurance and their diaphragm strength more than just breathing air during training. It also looks at how this affects the body's response to high CO2.See study design
What are the potential side effects?
Breathing in low concentrations of carbon monoxide can lead to slight oxygen deprivation which may cause headache, dizziness, nausea, or increased breathlessness. Long-term effects are not expected at these controlled exposure levels.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My physical fitness level is good, as measured by a specific test.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Arterial PCO2 change
Underwater endurance change
Ventilatory chemosensitivity change
Secondary outcome measures
Erythrocytes

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Respiratory Muscle Training Breathing Low Dose Carbon MonoxideExperimental Treatment1 Intervention
Carbon monoxide 200 ppm in air breathing during daily 30 minute inspiratory loading training sessions. Subjects will breathe the experimental gas through a mouthpiece with nose-clip in place.
Group II: Respiratory Muscle Training Breathing AirPlacebo Group1 Intervention
Air breathing during daily 30 minute inspiratory loading training sessions. Subjects will breathe air through a mouthpiece with nose-clip in place.

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor
2,356 Previous Clinical Trials
3,419,065 Total Patients Enrolled
Case Western Reserve UniversityOTHER
299 Previous Clinical Trials
260,034 Total Patients Enrolled
Richard E Moon, MDPrincipal InvestigatorDuke University
2 Previous Clinical Trials
38 Total Patients Enrolled

Media Library

Carbon monoxide 200 ppm in air Clinical Trial Eligibility Overview. Trial Name: NCT04679402 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people can take part in this experiment at once?

"Affirmative. Data hosted on clinicaltrials.gov verifies that this medical study, initially announced on April 14th 2022, is actively seeking participants. Approximately 60 individuals must be enrolled at a single site to complete the trial."

Answered by AI

Who qualifies for participation in this medical experiment?

"This clinical trial requires 60 volunteers aged between 18 and 45 who possess a respiratory system. In addition, the participants must be non-smokers with an appropriate hypercapnic ventilatory response as well as have VO2peak of at least thirty five mL.kg-1.min-1 (males) or thirty mL.kg-1.min-1 (females)."

Answered by AI

Can individuals still join this research endeavor?

"Per the clinicaltrials.gov website, this study is actively recruiting patients. It was first made available on April 14th 2022 and has since undergone its latest update on May 26th of this year."

Answered by AI

Can individuals aged 20 and above participate in this investigation?

"This clinical trial seeks to enrol patients from 18 to 45 years of age. For those younger or older than this range, there are supplementary trials with 1 for minors and 4 targeting seniors."

Answered by AI
~2 spots leftby Apr 2024