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Amino Acid
Low-tryptophan diet and L-tryptophan. for Diet Modification (Aryl-IMMUNE Trial)
N/A
Waitlist Available
Led By Premysl Bercik, MD, PhD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy volunteer between 18 and 75 years of age.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up three weeks.
Awards & highlights
Aryl-IMMUNE Trial Summary
This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.
Aryl-IMMUNE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowAryl-IMMUNE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ three weeks.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~three weeks.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
AHR activation levels in stool and duodenal content.
Secondary outcome measures
Bacterial and fungal microbiota composition in stool, duodenum and rectum/sigmoid biopsies.
Cytokines in serum.
Gastrointestinal symptoms
+3 moreAryl-IMMUNE Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Low-tryptophan diet and L-tryptophan.Experimental Treatment1 Intervention
Standardized low-tryptophan diet (500-1000 mg of L-tryptophan and 1800 kcal) + L-tryptophan supplements (3 g/day).
Group II: Low-tryptophan diet and placeboPlacebo Group1 Intervention
Standardized low-tryptophan diet (500-1000 mg of L-tryptophan and 1800 kcal) + placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-tryptophan
2017
N/A
~20
Find a Location
Who is running the clinical trial?
McMaster UniversityLead Sponsor
877 Previous Clinical Trials
2,596,040 Total Patients Enrolled
National Research Agency, FranceOTHER
68 Previous Clinical Trials
58,187 Total Patients Enrolled
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,333 Previous Clinical Trials
25,747,338 Total Patients Enrolled
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