This trial is evaluating whether minimal invasive pilonidal cystotomy will improve 1 primary outcome and 2 secondary outcomes in patients with Pilonidal Disease. Measurement will happen over the course of 30 days.
This trial requires 106 total participants across 2 different treatment groups
This trial involves 2 different treatments. Minimal Invasive Pilonidal Cystotomy is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"This review highlights that a substantial proportion of NTD affected individuals may become non-communicable diseases through the consequences of untreated infections such as those of onchocerciasis (River blindness) and ascariasis (Diva-Dry Eye). NTD are treated by applying topical and systemic antimicrobials. Antibiotics (for example, i.v. amoxicillin or macrolides) are used for many infections such as onchocerciasis, ascariasis and cysticercosis. Praziquantel is the drug recommended by the World Health Organization due to its low cost and easy availability. There are no effective vaccines for NTD." - Anonymous Online Contributor
"There is no data supporting a method of cure for the disease, and the current evidence on the subject is limited to anecdotal cure claims." - Anonymous Online Contributor
"Pilonidal disease does not appear to have an infectious or hereditary cause. There may be a genetic linkage to pilonidal sinus. The aetiology appears to be multifactorial with a probable link to the pilosebaceous unit." - Anonymous Online Contributor
"Since at least a decade, the CDC has reported a high rate of PD; however, no study had been conducted before 2005. The present study demonstrates an even higher rate, likely because of the longer average study period that exceeded the time frame used for previous studies. The rate of 0.05% (1.45/100,000) observed in the present study is approximately 2- to 3-fold higher than previous estimates. It is important to note that this rate is still slightly below the incidence of PD in Africa (1.6/100,000), but in recent years rates of PD have increased on the continent." - Anonymous Online Contributor
"Pilonidal disease is a chronic infection affecting the hair-follicle region of the skin resulting in the formation of nodules over the hair-follicle with infected hair which can detach and penetrate the layer of skin. The disease can be localized and may be asymptomatic as in pilonidal abscess in which case the disease is usually managed with careful skin healing and trimming of affected hair. In chronic case pilonidal scab may develop and lead to skin deterioration and in extreme cases pilonidal disease may penetrate the deep layers of skin resulting in cellulitis or abscess formation. To manage this case a well-planned and gentle medical evacuation with appropriate isolation and cleaning of the wound is required." - Anonymous Online Contributor
"Signs include discharge from the site, presence of a fistula, sinuses, bony enlargement and hard masses. All of these are typical signs and manifestations of pilonidal disease." - Anonymous Online Contributor
"Despite advances in modern treatment, more than half of pilonidal disease patients still has not recovered in the first 6 months. Moreover, one-half of the patients still needed recurrence surgeries. To find the best and more effective treatments with less recurrence rate." - Anonymous Online Contributor
"MIP is commonly used in conjunction with other treatments for patients with pilonidal disease. The addition of MIP did not offer significant advantages over surgery alone. For appropriately selected patients, MIP can be considered an effective approach in treating pilonidal disease." - Anonymous Online Contributor
"There are clinical trials for pilonidal disease in many countries worldwide, but there are many barriers in the procedure of undertaking these trials. For a better understanding and treatment of pilonidal diseases, we need to eliminate barriers. Those in developed countries can consider clinical trials for pilonidal disease. For those who are in developing countries, clinical trials should be encouraged to decrease the prevalence of pilonidal disease." - Anonymous Online Contributor
"Minimal invasive pilonidal cystotherapies were successful in 92.1% of all patients, whereas recurrence rate was 0%. Minimal invasive pilonidal cystotomy can be considered a treatment option in recurrent and difficult to treat cases but not necessarily in the first treatment step as this procedure has to overcome multiple surgical difficulties. There is no difference in terms of complications compared with traditional pilonidal cystectomy. More studies are needed to study minimal invasive pilonidal cystotherapy in other locations." - Anonymous Online Contributor
"Average age of infection was determined as 18.83 years for both genders. But pilonidal disease, especially on males, presents in various races, ethnicity, ages, and ages of infection." - Anonymous Online Contributor
"Although MIPC is currently the standard treatment technique even for larger cysts and larger cases, our results confirmed that MIPC can work equally well. However, one problem with MIPC is the high rate of recurrence. In all our cases, one or two operations were required to eliminate the cyst. We therefore strongly recommend a multidisciplinary panel discussion for this issue." - Anonymous Online Contributor