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Anti-metabolites

Methotrexate for Proliferative Vitreoretinopathy (SIGHT Trial)

Phase 1
Waitlist Available
Led By Edward Wood, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

SIGHT Trial Summary

This trial is testing whether methotrexate can help improve outcomes for children with retinal detachment caused by a tear.

SIGHT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Recurrence of Retinal Detachment

Side effects data

From 2015 Phase 3 trial • 139 Patients • NCT02001987
11%
Rheumatoid arthritis
11%
Rhinitis
9%
Asthenia
9%
Bronchitis
8%
Nasopharyngitis
8%
Alanine aminotransferase increased
8%
Arthralgia
8%
Headache
7%
Neutropenia
6%
Diarrhoea
5%
Back pain
5%
Transaminases increased
5%
Insomnia
5%
Hepatocellular injury
5%
Abdominal pain
4%
Urinary tract infection
3%
Injection site erythema
3%
Pruritus
3%
Ear infection
2%
Nausea
2%
Hypertension
1%
Angioedema
1%
Gastric ulcer
1%
Gastric volvulus
1%
Intestinal ischaemia
1%
Pulmonary embolism
1%
Deep vein thrombosis
1%
Hypertensive crisis
1%
Iron deficiency anaemia
1%
Cataract
1%
Cervical dysplasia
1%
Disseminated tuberculosis
1%
Septic shock
1%
Meningitis tuberculous
1%
Fall
100%
80%
60%
40%
20%
0%
Study treatment Arm
TCZ COMBO - All Participants
TCZ - All Participants
TCZ MONO - All Participants

SIGHT Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
Methotrexate treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methotrexate
FDA approved

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,374 Previous Clinical Trials
17,332,927 Total Patients Enrolled
Edward Wood, MDPrincipal InvestigatorStanford University
Quan Dong Nguyen, MD, MScPrincipal InvestigatorStanford University
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have other investigations been conducted with Methotrexate?

"Currently, 219 ongoing studies are examining the efficacy of Methotrexate with 67 Phase 3 trials. Although many of these research efforts center around New york City, there exist 7698 sites across the world where investigations into this drug are taking place."

Answered by AI

Has Methotrexate been granted authorization by the FDA?

"In light of the limited clinical data available to our team at Power, we have assigned Methotrexate a score of 1 on a scale from 1-3. This is due to it being in its first phase trial stage with minimal evidence for efficacy and safety."

Answered by AI

What maladies is Methotrexate most commonly employed to combat?

"Methotrexate is normally given to patients with small cell lung cancer, but it has also demonstrated efficacy in treating active pauciarticular juvenile rheumatoid arthritis, head and neck carcinoma, multiple sclerosis."

Answered by AI

What is the current sample size of participants for this research project?

"This clinical trial is no longer taking on applicants. It was initially posted April 1st 2021, with the most recent update being March 31st 2021. If you are looking for other studies related to vitreoretinopathy or methotrexate, there are 9 and 219 trials respectively recruiting participants at this time."

Answered by AI

Are there any ongoing opportunities to participate in this trial?

"Unfortunately, this trial is currently not recruiting participants. The information posted on 4/1/2021 and last edited on 3/31/2021 details the fact that it's no longer actively seeking patients. That said, there are presently 9 clinical trials searching for individuals with vitreoretinopathy proliferative as well as 219 studies scouting for Methotrexate users."

Answered by AI
~0 spots leftby Mar 2025