This trial is evaluating whether ALRN-6924 will improve 2 primary outcomes in patients with Non-Small Cell Lung Carcinoma (NSCLC). Measurement will happen over the course of Approximately 6 months.
This trial requires 35 total participants across 3 different treatment groups
This trial involves 3 different treatments. ALRN-6924 is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"The cure rate of SCLC varies according to tumor stage and treatment history. Although most SCLC cells are susceptible to treatment, more than two-thirds of previously treated patients present with recurrent disease." - Anonymous Online Contributor
"Small cell lung carcinoma presents with symptoms that have traditionally been associated with systemic disease. Consequently, the majority of patients require symptomatic treatment as well as systemic treatment. Treatment options must be carefully tailored in order to maximize survival and symptom control for each patient." - Anonymous Online Contributor
"SCLC may be a result of other diseases. The development of SCC is not clear, although viral infections such as HPV, KSHV, EBV, or a fungal infection are potential causes of SCC. The use of tobacco products could be a risk factor for SCC." - Anonymous Online Contributor
"Nodules detected on an HRCT are more commonly associated with SCLC. In particular, the presence of a mass effect of the nodule is highly suggestive of SCLC. Although a number of other imaging features are not as specific as a mass effect, they do contribute to the assessment of a case as potentially suggestive of a SCLC." - Anonymous Online Contributor
"Lung cancers have a high rate of metastatic metastatic disease. Lung cancer staging includes the TNM system which classifies the T and N stage of a tumor as local invasion and metastatic spread respectively. Stage IV disease is defined by a combination of metastatic spread and locally advanced disease. Stage IV disease is an indicator of an aggressive and highly lethal lung cancer disease." - Anonymous Online Contributor
"About 30,000 people in the United States will die of lung cancer each year. The prevalence of lung cancer is highest in black individuals and women with tobacco consumption. Lung cancer is second in men after colon cancer. A higher percentage of whites is likely to be diagnosed with lung cancer. A significantly higher mortality rate exists in black adults 25 years and older with lung cancer compared to whites." - Anonymous Online Contributor
"Patients who had a good performance status and small burden of symptoms reported a high burden of disease and were very likely to have a fatal outcome. The clinical and pathological features of the illness are the most important predictors of prognosis." - Anonymous Online Contributor
"Although [Alemtuzumab|alrn-6924|has|been approved in the USA for the treatment of SCLC] is being evaluated in clinical trials, alrn-6924 could be an even better choice for treatment of alveolar squamous cell carcinoma"
"Cypraeovula\n\nCypraeovula is a genus of sea snails, marine gastropod mollusks in the family Cypraeidae, the cowries." - Anonymous Online Contributor
"ALR-6924 is a promising lead compound for development of a treatment for SCLC. It has promising early pharmacology in preclinical studies and is well tolerated in subjects." - Anonymous Online Contributor
"The side effects related to pemetrexed were minimal. Thus, it is considered to be safe in alrn-6924 therapy. This drug can be helpful in preventing tumor relapse. In addition, alrn-6924 does not cause severe hematotoxicity or hepatotoxicity; therefore, alrn-6924 is considered to be one of the most useful agents in adjuvant chemotherapy. We, therefore, consider alrn-6924 to be one of the most effective compounds for use in breast cancer adjuvant chemotherapy." - Anonymous Online Contributor
"Alrn-6924 appears to affect multiple biological pathways in malignant cells, including tumor growth, angiogenic activity, survival, and migration. Further study of alrn-6924 and its other biological targets in malignant cells may lead to novel compounds that enhance or inhibit tumor responses to radiation therapy." - Anonymous Online Contributor
"Overall, this analysis demonstrated that most therapies tested were effective in treating SCLC, but the treatment duration must be increased in some groups because of the short time interval between diagnosis and therapeutic approach." - Anonymous Online Contributor