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Monoclonal Antibodies
Nab-paclitaxel, Gemcitabine + Bevacizumab for Cancer
Phase 1
Waitlist Available
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients with advanced or metastatic cancer that is refractory to standard therapy, relapsed after standard therapy, or have no standard therapy that induces a CR rate of at least 10% or improves survival by at least three months.
Patients should be at least four weeks from the last day of therapeutic radiation or cytotoxic chemotherapy or from antibody therapy, or at least five half-lives from non-cytotoxic targeted or biologic therapy. Patients may have received palliative radiation immediately before (or during) treatment provided radiation is not to the only target lesion available.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 2, 28 day cycles
Awards & highlights
Study Summary
The goal of this clinical research study is to find the highest tolerable dose of the combination of Abraxane (nab-paclitaxel), Gemzar (gemcitabine), and Avastin (bevacizumab) that can be given to patients with advanced cancer. The safety of this drug combination will also be studied.
Eligible Conditions
- Cancer
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ after 2, 28 day cycles
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 2, 28 day cycles
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Maximum Tolerated Dose (MTD) of Gemcitabine, Nab-Paclitaxel and Bevacizumab
Secondary outcome measures
Response Rate
Trial Design
1Treatment groups
Experimental Treatment
Group I: Nab-paclitaxel, Gemcitabine + BevacizumabExperimental Treatment3 Interventions
Starting doses of Nab-paclitaxel 50 mg/m^2, Bevacizumab 5 mg/kg + fixed dose of Gemcitabine 1000 mg/m^2
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bevacizumab
2013
Completed Phase 4
~5280
Gemcitabine
2017
Completed Phase 3
~2070
Nab-paclitaxel
2014
Completed Phase 3
~2030
Find a Location
Who is running the clinical trial?
M.D. Anderson Cancer CenterLead Sponsor
2,962 Previous Clinical Trials
1,803,180 Total Patients Enrolled
David S. Hong, MDStudy ChairM.D. Anderson Cancer Center
14 Previous Clinical Trials
385 Total Patients Enrolled
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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