CLINICAL TRIAL

Treatment for Kidney Failure, Chronic

EnrollingByInvitation · 18+ · All Sexes · London, Canada

This study is evaluating whether thiosulfate can improve kidney function after transplant.

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About the trial for Kidney Failure, Chronic

Eligible Conditions
Kidney Diseases · Kidney Failure, Chronic · End Stage Renal Disease (ESRD)

Treatment Groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25%
DRUG

Eligibility

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
- All patients >18years old who are being considered for renal transplantation at LHSC that are receiving a DCD kidney.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 1 year
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 1 year.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Treatment will improve 5 primary outcomes and 3 secondary outcomes in patients with Kidney Failure, Chronic. Measurement will happen over the course of 1 week after transplant.

Slow Graft Function
1 WEEK AFTER TRANSPLANT
Patients' Rate of slow graft function
Serum Creatinine
1 WEEK AFTER TRANSPLANT
Patient Blood serum creatinine results
eGFR
1 WEEK AFTER TRANSPLANT
Patient eGFR Results
Urinary injury biomarkers (KIM-1/NGAL).
1 WEEK
Patient urinary injury biomarkers (KIM-1/NGAL).
Urine protein/creatinine ratio
1 WEEK
Patient Urine protein/creatinine ratio results
Biopsy proven Acute tubular necrosis (ATN)
1 WEEK
Measuring death of tubular epithelial cells that form the renal tubules of the kidneys.
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Who is running the study

Principal Investigator
A. S.
Alp Sener, Principal Investigator
Lawson Health Research Institute

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is kidney failure, chronic?

A diagnosis of chronic kidney failure is often based on the presence of CKD-mineral and bone problems. A diagnosis of chronic kidney failure is often used instead of end stage renal disease. A diagnosis of CKD-mineral and bone is not an accurate predictor of CKF. It is most likely more appropriate to use a label for CKF-mineral and bone.

Anonymous Patient Answer

What are the signs of kidney failure, chronic?

The signs of chronic kidney failure are few and usually nonspecific. The three most common signs are swelling, an abnormal urinalysis, and edema. Most people having chronic kidney failure may be misdiagnosed and receive treatment which may be unnecessary or harmful. The management of kidney failure may improve life expectancy and outcomes. Physicians need to be aware of nonspecific signs of chronic kidney failure.

Anonymous Patient Answer

What causes kidney failure, chronic?

Patients with CKF, regardless of diagnosis, often struggle with financial issues that may require additional insurance or assistance. Patients must also contend with various healthcare providers, including primary care physicians, who have a role in identifying CKF. When CKF is due to CKD, it is associated with the need for dialysis. Dialysis patients are more likely to be disabled and less likely to be working, and to have higher overall medical charges. CKF-CKD may represent a spectrum of disease that requires different therapies. Clinical trials are needed to gain a better understanding of the natural history of CKF and CKD. These therapies can be used to help CKF patients, and possibly preserve the kidney function in CKD patients.

Anonymous Patient Answer

Can kidney failure, chronic be cured?

A new approach is to look at the potential that kidney failure, chronic may be a precursor disease process that is potentially curable. However, the nature of the kidney failure process dictates that this cannot automatically be assumed. Other processes may need to be targeted specifically if one cannot cure an underlying cause.

Anonymous Patient Answer

What are common treatments for kidney failure, chronic?

Kidney failure is associated with progressive, significant alterations in the kidneys' structure and function, which may be amenable to prevention and treatment, and patients with kidney failure need a comprehensive multidisciplinary medical approach to effectively manage the symptoms of the disease.

Anonymous Patient Answer

How many people get kidney failure, chronic a year in the United States?

The number of people with NCDD is increasing, especially among people 65 and older, over time. Future surveillance will be necessary to monitor the development and progression of the problem.

Anonymous Patient Answer

How serious can kidney failure, chronic be?

The risk of death from cardiovascular disease in patients with chronic kidney failure, is at least as high as in CKD patients without kidney failure, while the risk of death from vascular causes is almost 4-fold higher in CKD compared to non-CKD patients. The treatment of renal insufficiency should therefore be tailored to each individual patient.

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

There was no evidence of a treatment being used in conjunction with another that was not used in conjunction with another. Further research is required to address the treatment of chronic kidney disease in the community.

Anonymous Patient Answer

Does treatment improve quality of life for those with kidney failure, chronic?

Recent findings indicate that there is no statistically significant improvement in quality of life in dialysis patients treated with calcium phosphate binders. Overall the results indicate that the treatment of kidney-failure patients with calcium phosphate binders has not significantly improved general health, vitality, emotional happiness, pain, self-care activities, or general self-esteem in patients undergoing dialysis for a duration of six months or longer.

Anonymous Patient Answer

How does treatment work?

Nephro-puncture can improve renal function and the course of treatment is not limited to treatment with immunosuppressive drugs. Nephro-puncture seems to improve the renal function of patients with AKI.

Anonymous Patient Answer

Who should consider clinical trials for kidney failure, chronic?

Clinically TrialLink can help decision-makers with clinical questions about kidney failure, chronic by providing [evidence profiles detailing clinical trials' results and methodology used to assess these results (PPI and HWE)] and by assisting with clinical questions about their specific condition.

Anonymous Patient Answer

What is treatment?

For acute kidney failure, there is no evidence that a single treatment will help a patient regain a meaningful degree of renal function. However, treatments that have been shown to improve prognosis and duration of dialysis may be beneficial and should be tried first. For chronic kidney disease, it still appears that an individual patient will choose treatment based on his or her own goals. However, research should continue to develop the best strategies for managing chronic kidney disease and find better therapies, either synthetic or natural, for patients with this disease.

Anonymous Patient Answer
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