← Back to Search

Thiazolidinedione

Pioglitazone for Rheumatoid Arthritis

Phase 1
Waitlist Available
Led By Beatriz Hanaoka, MD MPH
Research Sponsored by Ohio State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 35-65
Diagnosed with RA by a Rheumatologist and according to American College of Rheumatology 2010 criteria
Timeline
Screening 3 weeks
Treatment Varies
Follow Up changes from baseline and 12 weeks
Awards & highlights

Study Summary

This trial will test if a medication called metformin, which is used to treat insulin resistance, can help improve muscle strength in patients with RA.

Eligible Conditions
  • Rheumatoid Arthritis
  • Insulin Resistance

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Insulin sensitivity
Monocytosis in peripheral blood
Skeletal muscle strength in the quadriceps muscle

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: PioglitazoneActive Control1 Intervention
From the total participants enrolled into the cross-sectional study, the investigator will identify up to 18 participants who have insulin resistance and recruit them to participate in the pioglitazone arm. Participants will start by taking increasing doses for three weeks as follows: 1 capsule (15 mg) per day for 7 days, 1 capsule per day (30 mg) for 7 days, and 1 capsule (45mg), if tolerated. Participants will continue this dose (45 mg) throughout the 12 weeks of treatment.
Group II: PlaceboPlacebo Group1 Intervention
From the total participants enrolled into the cross-sectional study, the investigator will identify up to 18 participants who have insulin resistance and recruit them to participate in the placebo arm. Participants will take matching placebo throughout the 15 weeks of treatment.

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Ohio State UniversityLead Sponsor
823 Previous Clinical Trials
501,187 Total Patients Enrolled
1 Trials studying Rheumatoid Arthritis
6 Patients Enrolled for Rheumatoid Arthritis
Beatriz Hanaoka, MD MPH3.98 ReviewsPrincipal Investigator - Ohio State University
University of Alabama at Birmingham
3Patient Review
I was very pleased with Dr. Hanaoka until she abruptly moved without any notice, which left me feeling frustrated and concerned. I had finally found a reliable doctor to treat my Lupus, and I don't want to make the same changes again only to be disappointed.

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Pioglitazone obtained regulatory approval from the FDA?

"Due to limited data supporting safety and efficacy, Pioglitazone was assigned a score of 1."

Answered by AI

Does this trial encompass individuals aged 40 or above?

"Eligibility requirements for this clinical trial restrict the age range of applicants to between 35 and 65 years old. There are 77 studies available for minors, while those aged above 65 have access to 445 different trials."

Answered by AI

May I have the privilege of participating in this research project?

"To be accepted into this medical trial, volunteers must demonstrate signs of insulin resistance and fall within a 35-65 year age range. A total of 36 individuals are required for the study."

Answered by AI

What is the size of the sample population for this investigation?

"Yes, the clinical trial is indeed still recruiting. According to data available on clinicatrials.gov, it was initially posted in September 2015 and updated most recently in May 2022. A total of 36 patients are sought from a single location."

Answered by AI

In what scenarios is Pioglitazone normally employed?

"Pioglitazone is the standard of care for diabetes, but it can also be beneficial in managing diabetic neuralgia and other conditions through dietary modifications and increased activity levels."

Answered by AI

Are there other investigations utilizing Pioglitazone currently available?

"Currently, 31 clinical trials on Pioglitazone are underway with 4 of them situated in phase 3. While Lausanne, Vaud has several studies dedicated to this drug, 69 research centres have such investigations taking place."

Answered by AI

Are there any remaining vacancies for participants in this medical experiment?

"Clinicaltrials.gov states that this research has been in active recruitment since its posting on September 1, 2015 and most recently updated on May 6th 2022."

Answered by AI
~2 spots leftby Mar 2025