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Natriuretic Peptide

MANP - 1st Cycle for Hypertension (MANP-2 Trial)

Phase 1
Waitlist Available
Led By Paul M McKie, M.D.
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 hours
Awards & highlights

MANP-2 Trial Summary

This trial will evaluate the cardiovascular properties of a drug called MANP in people with hypertension.

Eligible Conditions
  • Resistant Hypertension

MANP-2 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Blood Pressure
Secondary outcome measures
Glomerular filtration rate
Plasma aldosterone
Urinary cGMP excretion
+1 more

MANP-2 Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: MANP - 1st CycleActive Control1 Intervention
Subjects will receive a single SQ injection of 2.5 μg/kg MANP (n=10)
Group II: MANP - 2nd CycleActive Control1 Intervention
Subjects will receive a single SQ injection of 5 μg/Kg MANP (n=10)
Group III: Placebo - 1st CyclePlacebo Group1 Intervention
Subjects will receive a single SQ injection of placebo (0.9% normal saline) (n=10)

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,207 Previous Clinical Trials
3,766,860 Total Patients Enrolled
49 Trials studying Hypertension
46,978 Patients Enrolled for Hypertension
Paul M McKie, M.D.Principal InvestigatorMayo Foundation
2 Previous Clinical Trials
2,270 Total Patients Enrolled
1 Trials studying Hypertension
22 Patients Enrolled for Hypertension

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this medical experiment still have open slots for participants?

"Per the records on clinicaltrials.gov, this investigation is currently recruiting participants, having been initially posted in May 2018 and last edited February 2022."

Answered by AI

Who qualifies for inclusion in this medical experiment?

"This medical study is looking for 30 patients between the ages of 20 and 70 suffering from hypertension. The trial also requires that all participants are African American, have a BMI ranging between 18-40 kg/m2, and be able to communicate clearly with personnel involved in the research."

Answered by AI

Is MANP - 1st Cycle likely to cause any adverse effects in those who use it?

"Due to the limited evidence of safety and efficacy, our team has rated MANP - 1st Cycle as a 1 in terms of safety."

Answered by AI

Could you provide a summary of the preceding experiments performed with MANP - 1st Cycle?

"At this time, there are 28 active medical trials exploring the use of MANP-1st Cycle. Of those running studies, 5 have reached Phase 3 and many are located in Houston, TX with a total 1167 locations across all trial stages."

Answered by AI

Is participation in this trial open to seniors aged 65 and above?

"As specified in the trial's enrollment conditions, eligible participants must be between 20 and 70 years old."

Answered by AI

In what conditions is MANP - 1st Cycle commonly given to patients?

"MANP-1st Cycle is traditionally used to combat chilblains, and also has demonstrated efficacy in treating psoriasis, catarrh, and muscle strain."

Answered by AI

What is the maximum capacity for participants in this medical study?

"Affirmative. According to information on clinicaltrials.gov, this clinical trial is currently enrolling participants after having been posted on May 1st 2018 and updated most recently February 23rd 2022; 30 individuals are required from one medical facility."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
MANP in African Americans With Hypertension
Paul M. McKie, M.D. 2018. "MANP in African Americans With Hypertension". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04542681.
~0 spots leftby Apr 2025
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