Treatment for HIV Infections

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
San Francisco Gen Hosp, San Francisco, CA
HIV Infections
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a drug called PMPA can help people with HIV live longer.

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Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for HIV Infections

Trial Safety

Safety Progress

1 of 3

Other trials for HIV Infections

Trial Design

0 Treatment Group

This trial requires 60 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

San Francisco Gen Hosp - San Francisco, CA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
HIV infection, as indicated by seropositivity for HIV infection (ELISA and Western blot), positive HIV culture, or positive plasma HIV RNA.
CD4 cell count of 200 or more cells/mm3 within 28 days prior to study entry.
Plasma HIV RNA of 10,000 or more copies/ml within 28 days of study entry.
Minimum life expectancy of 12 months.

Patient Q&A Section

What are the signs of hiv infections?

"The general signs of HIV infections are swelling in one or more body parts. These can be found in people of all ages, although they are more prominent if the person has symptoms. Signs of diarrhea are also common, particularly in those who are young or sick. The presence of antibodies does not mean that a person is infected with HIV. This fact should be considered when HIV testing is performed." - Anonymous Online Contributor

Unverified Answer

What is hiv infections?

"It affects almost 5 million people in the world, and the number continues to grow at a faster rate. In the United States, the most densely populated area, an estimated 41,000 new cases will occur in 2008. It is estimated that 5.5 percent of males, ages 15 to 49, will develop a HIV infection, according to the World Health Organization's Joint United Nations Programme on HIV/AIDS. Most of those infected are in the developing world. A number of possible causes can be mentioned. These include high-risk heterosexual behavior, heterosexual or homosexual transmission of HIV from infected persons, risky sexual practice among HIV positive persons, and blood transfusions." - Anonymous Online Contributor

Unverified Answer

How many people get hiv infections a year in the United States?

"At least 8.8 million Americans are infected with HIV at some time in their life. This prevalence rate has risen significantly since 1990. The prevalence among gay males is five times that in the general population. This represents a public health crisis worldwide." - Anonymous Online Contributor

Unverified Answer

What are common treatments for hiv infections?

"Although HIV infection can cause a number of problems and can also be an indicator of other health problems, a number of treatment options are recommended. Although none of these treatments is efficient, they are generally quite safe. These are usually the first treatments mentioned when HIV infection occurs to a person with other health problems; however, this approach may be less effective at treating the underlying problems. Some of the most reliable treatments are those associated with the antiviral medications or with immunomodulatory agents." - Anonymous Online Contributor

Unverified Answer

Can hiv infections be cured?

"The current state of treatment options for hiv infections does not meet the basic scientific needs of curing hiv. The development of an AIDS vaccine or cure, or a vaccine for SIV that achieves an immunologic cure and can be broadly applied, are highly desirable." - Anonymous Online Contributor

Unverified Answer

What causes hiv infections?

"The most important risk factors include being in a long-term committed relationship with an infected partner, not using condoms, and having a family history of hiv. Most people who acquire hiv get it from partners who themselves recently acquired the virus. In many cases, the virus enters the body through sexual contact; however, many cases of HIV infection are thought to be the result of infection by an HIV-infected blood transfusion. Many people with hiv acquire HIV through the same mode of transmission as AIDS. While the vast majority of hiv infections occur in sub-Saharan Africa, hiv/AIDS is not necessarily a new disease. The earliest known case of hiv comes from Egypt in 1980." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"The majority of HIV patients are being treated with HAART (highly active antiretroviral therapy). When a patient needs immunosuppression for transplantation, bone marrow transplantation (BMT), or chemotherapy, the choice of regimen, including what drug combinations to use, is determined through the patient's specific circumstances and the drugs' side effects. While HAART is commonly used to treat HIV patients, it causes only partial control of viral load. Therefore, it cannot control viral load to a zero (and hence restore) level. In addition to control of viral load, BMT or chemotherapy can prevent or delay the development of HIV, but its usefulness depends on the extent of HIV infection and the type of AIDS-related illnesses." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for hiv infections?

"The potential for cure of HIV infection justifies the early enrollment of HIV-positive patients into clinical trials. In such trials, care must be taken to select patients with optimal immune function and limited residual viraemia for treatment." - Anonymous Online Contributor

Unverified Answer

How serious can hiv infections be?

"HIV is now a serious illness that frequently affects adolescents and young adults, particularly those who have sex with other people during this period of life, such as sex workers or those in the military. HIV is a leading cause of AIDS in the developed world and is responsible for an increasing proportion of adult deaths in the developing world as diagnosed cases of AIDS have increased." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"Most side effects are mild, and patients have only rarely complained of severe ones. There is no evidence that side effects vary by gender when given hormonal therapy. In our patients, the most common side effects were fatigue, swelling, and bloating. Hormonal therapy can also impair thyroid function, resulting in weakness, a very slow heartbeat and chest pain. It is important for patients to be aware of these side effects, especially if they are pregnant or if they are taking birth control pills. Most side effects are managed by changes in medication or by quitting or stopping medications. In summary, it does not appear that any side effect is so common or so severe that it is worth avoiding treatment." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"The treatment algorithms varied depending on a number of factors such as the age and immune status of the HIV+ patient. Most of these factors were ascertained from the initial clinical history of the patient at the first visit." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"Patients, their providers, and policymakers alike agree that timely, appropriate, and comprehensive cancer care is central to the goal of achieving optimal patient and provider outcomes. To address these challenges, we identified four specific gaps in care that must be addressed in the near term. The most important is an active program for expanding access to lung cancer care and awareness, particularly among high-risk populations. The second area of focus is the training and retention of appropriately trained clinical staff. The third is the development of an integrated health system that facilitates the delivery of appropriate and high-quality patient care. The fourth area is advocacy to improve the funding and reimbursement of lung cancer procedures and care, particularly for cancer patients with socioeconomic and educational disparities." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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