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Isoflurane for Heart Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Heart DiseaseIsoflurane - Drug
Eligibility
18+
All Sexes
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Study Summary

This trial will compare the effects of sevoflurane and isoflurane on the heart, using a special imaging software to measure heart function.

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Intraoperative period during cardiac surgery before initiation of cardiopulmonary bypass

Intraoperative period during cardiac surgery before initiation of cardiopulmonary bypass
Global longitudinal strain of myocardium, unitless (Comparison between two inhalational anesthetics, isoflurane and sevoflurane)
Global longitudinal strain of myocardium, unitless (Dose dependent effect of isoflurane)
Global longitudinal strain of myocardium, unitless (Dose dependent effect of sevoflurane)

Trial Safety

Safety Progress

1 of 3

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1
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1
Cardiomyopathy
1
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Trial Design

1 Treatment Group

Sevoflurane then isoflurane
1 of 1

Experimental Treatment

25 Total Participants · 1 Treatment Group

Primary Treatment: Isoflurane · No Placebo Group · Phase 1

Sevoflurane then isofluraneExperimental Group · 2 Interventions: Isoflurane, Sevoflurane · Intervention Types: Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Isoflurane
FDA approved
Sevoflurane
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: intraoperative period during cardiac surgery before initiation of cardiopulmonary bypass

Who is running the clinical trial?

Kathirvel SubramaniamLead Sponsor
5 Previous Clinical Trials
816 Total Patients Enrolled
Kathirvel Subramaniam, MD, MScPrincipal Investigator - University of Pittsburgh
University of Pittsburgh

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

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References

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