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Marizomib + Panobinostat for DIPG (DIPG Trial)
DIPG Trial Summary
This trial is looking at the safety and effectiveness of these drugs in children with a type of brain cancer called diffuse intrinsic pontine glioma (DIPG).
DIPG Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowDIPG Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2023 Phase 3 trial • 749 Patients • NCT03345095DIPG Trial Design
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Who is running the clinical trial?
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- I have a serious stomach or intestine problem.I am taking medication for epilepsy.You have any major health issues not related to the study.I am willing and able to follow the study's required visits, tests, and treatment plan.I am allergic to marizomib or panobinostat.You cannot receive a marizomib dose less than 0.2 mg.I can swallow pills without any issues.I am not taking any medication known to affect heart rhythm.You have any dangerous heart rhythm problems except for harmless early contractions in the lower chambers of the heart.I received my last strong chemotherapy dose more than 3 weeks ago, or 6 weeks if it was a specific type.I am not using substances that could cause confusion or dizziness.I have or had a brain condition called PRES.I have had a bone marrow transplant or intense therapy to destroy bone marrow.I have had or need urgent radiation therapy for my spine.It's been over 4 weeks since my last CED procedure, I don't have a permanent CED device, and I don't have current brain bleeding.It's been over 4 weeks since my last artery treatment, and I don't have any current bleeding in my tumor.I have received more than 60 Gy of radiation to the back part of my brain.You have a surgically implanted CED catheter.I have disclosed all supplements and alternative therapies I am using.I have recovered from side effects of my previous cancer treatments.I finished my radiation therapy at least 2 weeks ago.I have no ongoing side effects from previous treatments and it's been over a week since my last dose.My organs and bone marrow are working well.I have experienced confusion or hallucinations since my DIPG diagnosis.Blood transfusions do not work well for me.I have been diagnosed with DIPG.I am not currently on any cancer treatment or experimental drugs.I have had standard radiation therapy for my condition.I currently have or usually have diarrhea (4 or more times a day).I am under 22 years old.I can do most activities but may need help, based on a recent health score.
- Group 1: Marizomib
- Group 2: Marizomib + Panobinostat
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has the FDA sanctioned Marizomib for medical usage?
"Marizomib has only been tested in a limited capacity, so its safety is rated as a 1. There is minimal evidence that suggests it may be effective and safe for clinical use."
Is enrollment for this clinical experiment open at present?
"It appears that this investigation, initially posted on August 10th 2020 and last updated May 3rd 2022, is not currently admitting participants. Nevertheless, 815 other clinical trials are open to potential patients at the present moment."
Does this investigation introduce any novel therapeutic approaches?
"Marizomib has been in the spotlight since 2010, when Secura Bio, Inc. sponsored its first study involving 18 patients. This Phase 1 drug approval was granted following a successful trial and now 16 active studies are being conducted across 35 countries and 108 cities around the world."
How many participants are being enlisted in this experiment?
"At this juncture, no new candidates are being sought for the trial that was initially announced on August 10th 2020 and last modified on May 3rd 2022. Nonetheless, those seeking trials related to diffuse intrinsic pontine glioma can explore 799 active studies while 16 clinical trials utilizing Marizomib currently have open enrollment."
What research has been conducted on Marizomib in the past?
"Currently, there are 16 studies being conducted on Marizomib with 1 of those trials in its final phase. Although the bulk of these experiments take place at New york-based sites, a total of 285 locations have been utilised for examining this therapy."
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