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Lidocaine for Glioblastoma

Phase 1
Waitlist Available
Led By Kiarash Shahlaie
Research Sponsored by Kiarash Shahlaie, M.D., Ph.D.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
>= 18 years of age
Preoperative imaging characteristics consistent with brain glioblastoma (magnetic resonance imaging [MRI] brain)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 30 says after surgery
Awards & highlights

Study Summary

This trial is measuring the amount and effect of lidocaine injected into patients with glioblastoma during surgery to remove their brain tumors. Lidocaine is used to relieve pain. Information from this study may help researchers develop new treatments for patients with glioblastomas.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check β€œYes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 30 says after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 30 says after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference between the concentrations of lidocaine in the tumor tissue and in the blood (baseline level)
Secondary outcome measures
Incidence of adverse events (AEs)
Overall survival (OS)
Progression free survival (PFS)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Health services research (lidocaine, surgery)Experimental Treatment3 Interventions
Patients receive bolus lidocaine IV per standard of care. After intubation, patients receive another infusion of lidocaine IV over 4 hours or until the end of surgery. Patients also undergo collection of blood and tumor samples at the start of surgery and hourly afterwards until a total of 4 samples are collected.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biospecimen Collection
2004
Completed Phase 2
~1920
Lidocaine
2011
Completed Phase 4
~1360
Resection
2021
Completed Phase 2
~410

Find a Location

Who is running the clinical trial?

Kiarash Shahlaie, M.D., Ph.D.Lead Sponsor
National Cancer Institute (NCI)NIH
13,609 Previous Clinical Trials
40,915,634 Total Patients Enrolled
314 Trials studying Glioblastoma
22,434 Patients Enrolled for Glioblastoma
Kiarash ShahlaiePrincipal Investigator - University of California, Davis
Sutter General Hospital, University of California-Davis Medical Center
University Of California (Medical School)
University Ca Davis Health System (Residency)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent does Lidocaine pose a risk to human health?

"Due to the limited evidence of efficacy and safety associated with this Phase 1 trial, our team at Power has assigned Lidocaine a score of 1 on its risk assessment scale."

Answered by AI

Could you inform me of any other studies that have been conducted on the efficacy of Lidocaine?

"Presently, 118 trials are investigating the efficacy of using Lidocaine as a treatment. 31 of those medical studies have been approved for Phase 3 and 1094 locations across the world are contributing to this research. Notably, most of these live studies occur in Calgary, Alberta."

Answered by AI

What is the current enrollment size for this investigation?

"At this moment, this clinical trial is not enrolling patients. Its first post was on the 20th of January 2021 and its most recent edit occurred a year later. If you are seeking other studies that may be suitable for your needs, 442 trials with glioblastoma and 118 trials using lidocaine are currently accepting participants."

Answered by AI

What medicinal purposes does Lidocaine typically serve?

"Generally, lidocaine is prescribed to manage cervical syndrome. Furthermore, this medication can be used to address minor burns, transplantation issues and even osteoporosis."

Answered by AI

Are enrollment opportunities still available for the trial?

"According to clinicaltrials.gov, this trial is no longer seeking enrolment candidates. Initially posted on January 20th 2021 and last updated on January 21st 2022, the study has since closed its recruitment window. Despite that fact, 560 other trials are presently recruiting patients for their respective studies."

Answered by AI
~3 spots leftby Mar 2025