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Typhoid Vaccine, then Normal Saline for Depression
Phase 1
Waitlist Available
Led By Sudhakar Selvaraj, 7134862627
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy volunteers, male or female; aged 18-65
Subjects with history of Major depression (currently asymptomatic - symptom free for more than 6 months)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-6 hours post-injection
Awards & highlights
Study Summary
This trial will compare the effects of a mild inflammatory stimulus on healthy volunteers vs. those with a history of Major Depressive Disorder.
Eligible Conditions
- Depression
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3-6 hours post-injection
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-6 hours post-injection
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Inflammation as indicated by cytokines
Change in depressed mood as indicated by Hamilton Depression Rating Scale (HAM-D) score
Level of prefrontal, limbic and striatal cortex activation as indicated by fMRI
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Typhoid Vaccine, then Normal SalineExperimental Treatment2 Interventions
0.5 ml of S.typhi injection, then 0.5 ml of normal saline injection
Group II: Normal Saline, then Typhoid VaccinePlacebo Group2 Interventions
0.5 ml of normal saline injection, then 0.5 ml of S.typhi injection
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Normal Saline Injection
2011
Completed Phase 2
~70
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
The University of Texas Health Science Center, HoustonLead Sponsor
902 Previous Clinical Trials
320,885 Total Patients Enrolled
18 Trials studying Depression
3,066 Patients Enrolled for Depression
Sudhakar Selvaraj, 7134862627Principal Investigator - Prinicpal Investigator
The University of Texas Health Science Center, Houston
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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