This trial is evaluating whether Acetate (Apple Cider Vinegar) will improve 5 primary outcomes and 5 secondary outcomes in patients with Depression. Measurement will happen over the course of 5 months, captured monthly.
This trial requires 10 total participants across 1 different treatment group
This trial involves a single treatment. Acetate (Apple Cider Vinegar) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"There is no single treatment that can cure depression, but there are several approaches that can provide some relief from symptoms. Common medications include antidepressants, psychotherapy of various types, and, for more serious forms of depression, electroconvulsive therapy and psychosurgery. A full investigation of treatment is advised before making any definite recommendations." - Anonymous Online Contributor
"Based on national estimates from the CDC National Center for Complementary and Alternative Medicine, approximately 812 million Americans (10.2 million in women and 7.5 million in men) were being treated for depression in 2001 in the United States. These estimates suggest that depressed mood may affect approximately two men and three women per 100 people annually in the United States." - Anonymous Online Contributor
"Depression is a mental disorder characterized by chronic feelings of sadness, low mood, sleep disturbances and feelings of hopelessness and worthlessness for at least two weeks. About one in ten people will develop depression in their lifetime. The most common age group affected is the elderly. Older people with depression tend to have a number of medical and psychological illnesses with potential to exacerbate depression. As such it is important to make the diagnosis, and most importantly, detect and treat depression in people with cancer." - Anonymous Online Contributor
"A systematic search reveals only one study in which CCA treatment as a monotherapy was investigated for the treatment of generalized anxiety disorder (GAD) with positive results. A second random double blinded study examining the effect of CCA on anxiety in children with bipolar disorder shows significant improvement in anxiety but no significant reduction in depressive symptoms. There has never been a randomized controlled trial assessing CCA for depression and anxiety. A double blinded cross over study comparing CCA and placebo for treating chronic fatigue syndrome (CFS) found significant benefit in reducing the severity of depressive symptoms and in relieving the symptoms of fatigue and soreness after treatment, but no significant improvement in overall fatigue or quality of life, or in the number of tender points." - Anonymous Online Contributor
"ACV is used as a dietary supplement and, in doses used during treatment of gastric ulcers and colic, is not toxic in humans. It is also used as a topical ointment for the treatment of dandruff. Despite its common use as a dietary supplement and topical ointment and despite its supposed efficacy in treating a variety of conditions including ulcers, inflammation, sprains and strains, this meta-analysis of published studies has not shown any beneficial effect in humans with a variety of symptoms of a physiological or psychological nature including depression. It is an active ingredient in a number of popular over-the-counter (OTC) dietary or topical supplements which may increase exposure and hence adverse effects." - Anonymous Online Contributor
"Acetate has many different effects on the body, including a positive impact on liver enzymes and decreasing inflammation. It works to clear out old fat in your body and it may work to decrease inflammation in your brain." - Anonymous Online Contributor
"Recent findings of this survey suggest that a majority of patients and clinicians would perceive clinical trials on depression treatment as appropriate in an individual on an institutional level. However, barriers still remain in order for such trials to be realized and implemented for actual clinical use." - Anonymous Online Contributor
"Anhedonia is commonly one of the initial depressive symptoms or a secondary depressive feature associated with major depression. For the purpose of screening, an instrument like TMD-AI is sufficient even though the instrument is only able to exclude depression in less than two third of patients." - Anonymous Online Contributor
"Major depressive episodes are often caused by adverse life circumstances, health-related problems, and stressful life events. Minor depression has many different causes ranging from low serotonin levels to genetics. Although it is difficult to ascertain the exact causes, it is possible that an interaction between genetic and environmental factors may be involved in the development of major depression, resulting in the individual experiencing a long-term depression that begins with a minor depressive episode." - Anonymous Online Contributor
"This finding indicates that there may be no cure for depression. In a minority of cases an improvement is seen after some period of time when the symptoms lessen, but in the majority of cases the condition deteriorates and the symptoms become more severe over time. A significant number of people remain in a chronically depressed state despite the occurrence of remission of the initial depressive symptoms. The treatment of depression may need to be continued in more severe cases throughout the life of the sufferer." - Anonymous Online Contributor
"Apple cider vinegar is a widely used natural dietary supplement. While the majority of side effects reported herein were mild, a few can be serious and necessitate immediate medical attention. Acute overdoses can lead to seizure, coma, death, and, in some cases, acute liver failure. Patients with known hypersensitivity to acetic (vinegar) and/or intolerance to any ingredient found in acetate may not react as well as others. In the event of a patient not reacting, a complete nutritional assessment is recommended prior to discontinuing the supplementation due to symptoms of a medical condition or disease." - Anonymous Online Contributor
"We found the research reviewed to be somewhat mixed, but indicated there was some evidence that depression may be related to poor sleep and early life experiences. We recommend that health professionals review the latest relevant evidence on depression and mental health services to support their clinical practice." - Anonymous Online Contributor