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Histone Deacetylase Inhibitor; Tyrosine Kinase Inhibitor
Escalating doses of imatinib and LBH589 for Chordoma
Phase 1
Waitlist Available
Led By Deric M Park, MD
Research Sponsored by Deric M Park MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients greater than or equal to 18 years of age.
Histologically documented diagnosis of chordoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12
Awards & highlights
Study Summary
This is a multi-center study to assess the safety and to determine the maximum tolerated dose of the combination of imatinib and LBH589 in patients with newly diagnosed and recurrent chordoma. For the recurrent population, those patients that do not require immediate surgical resection will be eligible. Patients will be treated with 4 cycles, followed by surgical resection if possible. If indicated, surgery may take place prior to the completion of 4 cycles.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at time of study drug discontinuation
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at time of study drug discontinuation
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of dose limiting toxicities
Secondary outcome measures
Tumor response
Trial Design
1Treatment groups
Experimental Treatment
Group I: Escalating doses of imatinib and LBH589Experimental Treatment1 Intervention
Study will incorporate a "3+3" dose escalation design.
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Who is running the clinical trial?
Deric M Park MDLead Sponsor
Deric M Park, MDPrincipal InvestigatorUniversity of Virginia
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who else is applying?
What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1
What questions have other patients asked about this trial?
Do I have to pay for the treatment?
How long will my treatment process take?
PatientReceived 2+ prior treatments
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