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Histone Deacetylase Inhibitor; Tyrosine Kinase Inhibitor

Escalating doses of imatinib and LBH589 for Chordoma

Phase 1
Waitlist Available
Led By Deric M Park, MD
Research Sponsored by Deric M Park MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients greater than or equal to 18 years of age.
Histologically documented diagnosis of chordoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12
Awards & highlights

Study Summary

This is a multi-center study to assess the safety and to determine the maximum tolerated dose of the combination of imatinib and LBH589 in patients with newly diagnosed and recurrent chordoma. For the recurrent population, those patients that do not require immediate surgical resection will be eligible. Patients will be treated with 4 cycles, followed by surgical resection if possible. If indicated, surgery may take place prior to the completion of 4 cycles.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at time of study drug discontinuation
This trial's timeline: 3 weeks for screening, Varies for treatment, and at time of study drug discontinuation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of dose limiting toxicities
Secondary outcome measures
Tumor response

Trial Design

1Treatment groups
Experimental Treatment
Group I: Escalating doses of imatinib and LBH589Experimental Treatment1 Intervention
Study will incorporate a "3+3" dose escalation design.

Find a Location

Who is running the clinical trial?

Deric M Park MDLead Sponsor
Deric M Park, MDPrincipal InvestigatorUniversity of Virginia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

What questions have other patients asked about this trial?

Do I have to pay for the treatment? How long will my treatment process take?
PatientReceived 2+ prior treatments
~3 spots leftby Mar 2025