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AMG 890 for Cardiovascular Disease

Phase 1
Waitlist Available
Research Sponsored by Amgen
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Other Inclusion criteria may apply
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 365 days
Awards & highlights

Study Summary

This trial is testing a new drug to see if it's safe and effective at reducing levels of Lipoprotein(a) in the blood.

Eligible Conditions
  • Cardiovascular Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
There may be additional requirements for eligibility that are not listed here.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 365 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 365 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in PR interval
Changes in QRS interval
Changes in QT interval
+20 more
Secondary outcome measures
Change in plasma Lp(a) over time
Percent change in plasma Lp(a) over time
Pharmacokinetics parameter of area under the concentration time curve (AUC)
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AMG 890Experimental Treatment1 Intervention
Single Ascending Dose Cohorts
Group II: PlaceboPlacebo Group1 Intervention
Single Ascending Dose Cohorts
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AMG 890
2018
Completed Phase 1
~80

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

AmgenLead Sponsor
1,359 Previous Clinical Trials
1,384,432 Total Patients Enrolled
MDStudy DirectorAmgen
902 Previous Clinical Trials
922,087 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what extent has the Food and Drug Administration sanctioned AMG 890?

"The safety of AMG 890 has been estimated at a 1 due to this being an early-phase trial, with limited evidence attesting to its efficacy and safety."

Answered by AI

What is the scope of this medical experiment in terms of number of hospitals?

"This medical trial has recruited 6 sites, including the University of Kansas Medical Center in Kansas City and Excel Medical Clinical Trials in Boca Raton. Additionally, QPS Miami Research Associates located in South Miami is a participant as well."

Answered by AI

Is the age threshold for participation in this clinical trial greater than 60 years?

"According to the enrollment criteria of this medical investigation, those aged between 18 and 70 are eligible for participation."

Answered by AI

What qualifications must an individual possess in order to be considered eligible for this trial?

"This medical study seeks 79 adult participants with cardiovascular disease and a BMI between 18-40 who have elevated plasma Lp(a) levels. Additionally, female volunteers must be of non-reproductive standing while other criteria may also apply."

Answered by AI

Are there still openings for this experiment to be conducted on individuals?

"This trial, first published on July 30th 2018, is no longer recruiting participants according to clinicaltrials.gov. Nonetheless, 423 alternative scientific studies are currently seeking volunteers."

Answered by AI
~12 spots leftby Mar 2025