This trial is evaluating whether DCR-AUD will improve 2 primary outcomes and 9 secondary outcomes in patients with Alcoholism. Measurement will happen over the course of 24 weeks.
This trial requires 36 total participants across 8 different treatment groups
This trial involves 8 different treatments. DCR-AUD is the primary treatment being studied. Participants will be divided into 4 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
Participation is compensated
You will be compensated for participating in this trial.
"Given existing evidence about the effectiveness of treatment for individuals with alcoholism, it is uncertain whether any clinician will be persuaded to consider conducting a clinical trial or whether clinicians will feel confident that they can influence the decisions of people with alcoholism." - Anonymous Online Contributor
"Dcr-aud is a widely used non-invasive application. Based on the number of reports in existing literature, DCR-Aud seems to be well accepted by a large number of patients and seems to have little effect on the daily life activities of the patients treated with this procedure. We would therefore recommend its use to this patient group." - Anonymous Online Contributor
"Alcoholism appears to be quite common in adults and substantially affects the lives of millions of older Americans. As of 2008, it is estimated that 24% of American males over the age of 55 and 6 % of those over the age of 65 have lifetime alcohol dependency. A substantial number of these individuals can be considered heavy drinkers: approximately 25% of women and 20% of men over the age of 55 had more than 30 standard drinks per day during the past year (not including alcohol in alcoholic beverages such as wine, beer or spirits). More than 25 million Americans over the age of 55 are heavy drinkers." - Anonymous Online Contributor
"Alcoholics commonly experience abnormal sensations, hallucinations, sweating, and abdominal discomfort. In severe cases of alcoholism, a person may experience delirium tremens, disorientation, and acute alcohol poisoning. However, in lesser cases of alcoholism, the symptoms of intoxication do not occur for the alcoholic person but only for people who drink from the same cup that was used to empty the alcoholic person. It is important to tell a loved one about these symptoms if the alcoholic is drinking." - Anonymous Online Contributor
"Alcoholism is a chronic disorder, not a single cause. There are several risk factors for alcoholism, including low IQ and socioeconomic status, but the nature and strength of the link between alcoholism and these factors are controversial. On these questions, the strongest scientific evidence suggests that, for low IQ or a limited education, there may not be any increased risk, and that familial factors may be involved, but these do not always explain the higher-than-normal risks for alcoholics with more than two or three children. Further work is needed to replicate the relative role of various risk factors." - Anonymous Online Contributor
"Alcoholism is defined as a chronic alcoholism for which there is a prolonged dependence. This chronic form of alcoholism can lead to physical illnesses such as an increased risk of developing liver disease and cancers of the blood or other tissues. Alcoholism is a global problem and the majority of people who drink alcohol are heavy drinkers. More than 80 percent of the World's population is affected.\n" - Anonymous Online Contributor
"Alcoholism is often treated with long-acting benzodiazepines such as diazepam or clonazepam for the anxiety produced, while short-acting benzodiazepines are used for the insomnia. Long-acting benzodiazepines are sometimes switched to shorter-acting benzodiazepines in a person who can not sleep by themselves. Antidepressants may be used alone or as an adjunct to benzodiazepines in the treatment of the anxiety. A low-calorie diet is advised. In some cases, patients may benefit from other forms of treatment that may include cognitive behavioral therapy, a motivational interviewing by a professional, a residential care program, and supported housing as part of a chronic disease management plan in some places." - Anonymous Online Contributor
"With appropriate treatment, only a minority will remain alcoholic regardless of the initial severity of their disorder. The key to long-term rehabilitation appears to be early detection and adequate treatment of relapse." - Anonymous Online Contributor
"Almost half of the patients (46 %). of patients were dependent, and 15 % were co-dependent, with another 20 % of patients who met the WHO criteria for dependence having a tendency towards dependency. About a third of the patients were alcoholic-only. Those who are alcoholic-only have a lower prevalence of other substance dependence, but dependence rates were in comparable range of those who are dependent." - Anonymous Online Contributor
"There is a lot of promise regarding the use of stem cells for treating alcoholism, but more research may be necessary before such treatments can be fully considered for clinical use. There is a good amount of evidence that alcoholism is caused by neurological changes, but the exact mechanism can't be identified. To treat alcoholism, it may be necessary to treat the brain separately. More information on treatments for alcoholism will help decrease future alcoholics' risks for developing heart disease and liver disease." - Anonymous Online Contributor
"Findings from a recent study suggest that DCR-Aud facilitates the induction of alcohol-induced sensitization to the GABA(b) receptor. The mechanism of action of DCR-Aud seems to be mediated by an interaction of (1) the benzodiazepine core structural feature of this class of compounds and (2) the benzodiazepine ring side chains." - Anonymous Online Contributor
"Alcoholism is a chronic disorder that involves prolonged social impairment, psychiatric illnesses, alcohol-related deaths, and alcoholism-induced deaths. Chronic alcoholism may cause damage to liver, brain, heart, kidneys, skeletal muscles, and eyes. Alcoholism may be prevented by educating people on the adverse consequences of alcohol use and counseling those afflicted by alcohol." - Anonymous Online Contributor