Probenecid for Alcoholism

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
AlcoholismProbenecid - Drug
Eligibility
21 - 70
All Sexes
What conditions do you have?
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Study Summary

This trial tests the effects of probenecid, given as a single 2g dose, on alcohol intoxication in humans. The trial is double-blind, meaning that neither the participants nor the staff administering the drug will know who is receiving probenecid or placebo. The study is also placebo-controlled, meaning that a group of participants will receive a placebo (a 'sugar pill') instead of probenecid.

Eligible Conditions
  • Alcoholism

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Change from Day 3 to day 10 of the trial

Day 10
Alcohol craving
Sedative effects of alcohol when co-administered with drug or matching placebo
Stimulant effects of alcohol when co-administered with drug or matching placebo

Trial Safety

Safety Progress

1 of 3

Side Effects for

Probenecid
13%Migraine
13%Sore Throat
13%Nausea
13%Rhinovirus
This histogram enumerates side effects from a completed 2020 Phase 4 trial (NCT03965351) in the Probenecid ARM group. Side effects include: Migraine with 13%, Sore Throat with 13%, Nausea with 13%, Rhinovirus with 13%.

Trial Design

2 Treatment Groups

Probenecid
1 of 2
matching placebo
1 of 2

Experimental Treatment

Non-Treatment Group

34 Total Participants · 2 Treatment Groups

Primary Treatment: Probenecid · Has Placebo Group · Phase 1

Probenecid
Drug
Experimental Group · 1 Intervention: Probenecid · Intervention Types: Drug
matching placebo
Drug
PlaceboComparator Group · 1 Intervention: Matching placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Probenecid
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: change from day 3 to day 10 of the trial

Who is running the clinical trial?

Brown UniversityLead Sponsor
413 Previous Clinical Trials
518,425 Total Patients Enrolled
27 Trials studying Alcoholism
5,065 Patients Enrolled for Alcoholism
Carolina L Haass-Koffler, PHARMDPrincipal InvestigatorBrown University
1 Previous Clinical Trials
184 Total Patients Enrolled
1 Trials studying Alcoholism
184 Patients Enrolled for Alcoholism

Eligibility Criteria

Age 21 - 70 · All Participants · 6 Total Inclusion Criteria

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