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Dexmedetomidine for Healthy Subjects
Phase 1
Waitlist Available
Led By Michael T Alkire, MD
Research Sponsored by Southern California Institute for Research and Education
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy adults.
Between the ages of 18 and 35.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
Study Summary
This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ day 4
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 4
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of events remembered
Secondary outcome measures
Event-related fMRI BOLD signals
Other outcome measures
Tolerability
Trial Design
5Treatment groups
Experimental Treatment
Placebo Group
Group I: PropofolExperimental Treatment1 Intervention
Propofol intravenous infusion during scan.
Group II: Nitrous OxideExperimental Treatment1 Intervention
Nitrous Oxide inhalation during scan.
Group III: KetamineExperimental Treatment1 Intervention
Ketamine intravenous infusion during scan.
Group IV: DexmedetomidineExperimental Treatment1 Intervention
Dexmedetomidine intravenous infusion during scan.
Group V: PlaceboPlacebo Group5 Interventions
Placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitrous oxide
FDA approved
Ketamine
FDA approved
Dexmedetomidine
FDA approved
Propofol
FDA approved
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
University of California, IrvineOTHER
536 Previous Clinical Trials
1,921,307 Total Patients Enrolled
Southern California Institute for Research and EducationLead Sponsor
26 Previous Clinical Trials
1,491 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,771 Previous Clinical Trials
2,645,002 Total Patients Enrolled
Frequently Asked Questions
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