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Sublingual Lobeline for Methamphetamine Addiction

Phase 1
Waitlist Available
Led By Reese Jones, M.D.
Research Sponsored by National Institute on Drug Abuse (NIDA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must have a body mass index between 18 and 30
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial will test if it's safe to give lobeline under the tongue, and how it affects the body.

Who is the study for?
This trial is for healthy volunteers who can consent to the study, have no medical issues based on exams and tests, are not currently using drugs (confirmed by a drug test), and if female and able to have children, agree to use birth control. Participants must also have a body mass index (BMI) between 18 and 30.Check my eligibility
What is being tested?
The study is testing different doses of Lobeline (30, 45, and 60 mg) taken under the tongue to see how safe it is and how the body processes it. This research could help in treating methamphetamine addiction.See study design
What are the potential side effects?
While specific side effects aren't listed here, generally such trials look out for any adverse reactions ranging from mild discomfort at the application site to more systemic responses like nausea or headaches.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My BMI is between 18 and 30.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Tolerability
Secondary outcome measures
Cardiovascular responses
Pharmacokinetic parameters
Psychological effects of lobeline
+1 more

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)Lead Sponsor
2,455 Previous Clinical Trials
2,596,968 Total Patients Enrolled
1 Trials studying Methamphetamine Addiction
8 Patients Enrolled for Methamphetamine Addiction
Reese Jones, M.D.Principal InvestigatorLangley Porter Psychiatric Institute
4 Previous Clinical Trials
64 Total Patients Enrolled

Media Library

Sublingual Lobeline (Other) Clinical Trial Eligibility Overview. Trial Name: NCT00519259 — Phase 1
Methamphetamine Addiction Research Study Groups:
Methamphetamine Addiction Clinical Trial 2023: Sublingual Lobeline Highlights & Side Effects. Trial Name: NCT00519259 — Phase 1
Sublingual Lobeline (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00519259 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially join this trial as a participant?

"This clinical trial aims to recruit 12 individuals, aged 18-45 years old with methamphetamine dependence. To be considered for the study, participants must have a healthy BMI of between 18 and 30 as well as need to provide evidence of abstinence via drug screening tests."

Answered by AI

Are recruitment efforts underway for this research undertaking?

"As verified on clinicaltrials.gov, this experiment is no longer enrolling participants; it was initially posted in February 2006 and last edited in January 2017. However, 18 other trials are currently accepting patients for their studies."

Answered by AI

Does this treatment have the stamp of approval from the Food and Drug Administration?

"The safety of this treatment is rated at a 1 due to the limited clinical evidence available, as it's currently in Phase 1 trials."

Answered by AI

Does this trial accommodate patients who are over sixty years old?

"Individuals who are between 18 and 45 years old may be eligible for enrollment in this research trial."

Answered by AI

Who else is applying?

What state do they live in?
Arizona
California
How old are they?
18 - 65
What site did they apply to?
Langley Porter Psychiatric Institute
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
~1 spots leftby Mar 2025