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Metoprolol Succinate for Long COVID (PEACE Trial)
PEACE Trial Summary
This trial is testing a potential treatment for the post-acute COVID 19 syndrome (PASC). The symptoms of this condition are highly variable and often extraordinarily debilitating, and as of July 2021 it qualifies as a disability under the Americans with Disabilities Act. The trial is testing whether the treatment can help patients who have these symptoms and who have had COVID-19.
PEACE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPEACE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PEACE Trial Design
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- You have an abnormal heads up tilt test.You have a fever or an infection.You are currently being treated for a pre-existing condition that causes fainting or low blood pressure.Your Zva score is higher than 3.5 based on a heart ultrasound test.You have an overactive thyroid.Your hemoglobin and hematocrit levels are within the normal range according to lab tests.You are currently pregnant.You are currently taking beta blocker medications.You should be between 18 and 40 years old and have been experiencing shortness of breath during physical activity for 3 to 12 months.You have recently recovered from a positive COVID-19 test.You experience fast heart rate and/or shortness of breath with very little activity, different from how you felt before getting COVID-19.You have a normal chest x-ray.Show that the main reason for your rapid heart rate is from appropriate physical activity or sinus tachycardia.You had an abnormal heads up tilt test.You are currently going through withdrawal from alcohol, drugs, or medications.You have low levels of red blood cells.You have very low blood volume.You have gotten better from COVID-19 and your symptoms have improved a lot.Your heart's pumping ability is greater than 50% as measured by a heart ultrasound.You have a history of long-term lung problems or reactive airway syndrome.Your thyroid-stimulating hormone (TSH) levels are within the normal range according to lab tests.You should be between 18 and 40 years old and have had trouble breathing during physical activity for 3 to 12 months.You have fast heartbeat or trouble breathing with little physical activity, which is different from before you had COVID-19.
- Group 1: Study arm - Metoprolol Succinate.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Have there been other investigations concerning the efficacy of Metoprolol Succinate?
"Currently, 21 trials examining the efficacy of Metoprolol Succinate are underway with 4 in Phase 3. Although most studies take place in Orlando, Florida there are a total of 144 sites conducting research on this medication."
What therapeutic applications is Metoprolol Succinate typically used for?
"Metoprolol Succinate is a popular choice for hemodynamically stable patients, as well as those with angina pectoris, atrial fibrillation or hypertensive disease."
Does my medical history qualify me to join this research endeavor?
"We are in search of 20 participants aged 18-40 who have been suffering from tachycardia and/or dyspnea with minimal activity for 3 to 12 months. Additionally, the abnormal results on a HUTT (heads up tilt test) should be noted upon application."
Are there any enrollments still available for participants?
"According to clinicaltrials.gov, this health research project is currently in search of suitable participants. This study was initiated on March 23rd 2022 and revised two days later."
How many participants have enrolled in this experiment thus far?
"Confirmed. Clinicaltrials.gov data supports the fact that this clinical trial is currently admitting patients, with the first posting being made on March 23rd 2022 and most recent update occurring two days later. The study needs to fill 20 positions at a single location."
Is enrollment open to those younger than 85 years of age for this research?
"The eligibility requirements for this study necessitate that applicants must be between the ages of 18 and 40. In contrast, there are 157 trials available to minors while 1047 studies permit those beyond retirement age."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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