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Beta Blocker

Metoprolol Succinate for Long COVID (PEACE Trial)

Phase < 1
Waitlist Available
Led By David Landers, MD
Research Sponsored by Hackensack Meridian Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subject should be between the ages of 18 and 40 with DOE (dyspnea on exertion) for 3 - 12 months
Subjects recovered from acute, polymerase chain reaction (PCR) positive, COVID-19 infection
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks from baseline
Awards & highlights

PEACE Trial Summary

This trial is testing a potential treatment for the post-acute COVID 19 syndrome (PASC). The symptoms of this condition are highly variable and often extraordinarily debilitating, and as of July 2021 it qualifies as a disability under the Americans with Disabilities Act. The trial is testing whether the treatment can help patients who have these symptoms and who have had COVID-19.

Who is the study for?
This trial is for individuals aged 18-40 who've recovered from COVID-19 but experience shortness of breath and rapid heartbeat with minimal activity, lasting 3-12 months. They must have normal heart function, blood counts, and thyroid levels, without chronic lung issues or other conditions like dysautonomia.Check my eligibility
What is being tested?
The study tests Metoprolol Succinate's effectiveness in treating long-term symptoms after COVID-19 recovery—specifically difficulty breathing on exertion and associated fast heartbeat.See study design
What are the potential side effects?
Metoprolol may cause dizziness, fatigue, depression, shortness of breath during exercise, insomnia, or unusual dreams. It can also slow down the heart rate too much.

PEACE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You should be between 18 and 40 years old and have been experiencing shortness of breath during physical activity for 3 to 12 months.
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You have recently recovered from a positive COVID-19 test.
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You experience fast heart rate and/or shortness of breath with very little activity, different from how you felt before getting COVID-19.
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You have gotten better from COVID-19 and your symptoms have improved a lot.

PEACE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks from baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks from baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 6 minute walk test at the end of treatment period
Change in Zva measurement at the end of treatment period
Secondary outcome measures
Heart failure

PEACE Trial Design

1Treatment groups
Experimental Treatment
Group I: Study arm - Metoprolol Succinate.Experimental Treatment1 Intervention
The beta blocker metoprolol succinate will be initiated at a starting low dose of 25 mg daily for two weeks and will be escalated if well tolerated every 2 weeks to a maximum dose of 400 mg po daily.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metoprolol Succinate
2023
Completed Phase 4
~2030

Find a Location

Who is running the clinical trial?

Hackensack Meridian HealthLead Sponsor
131 Previous Clinical Trials
28,230 Total Patients Enrolled
7 Trials studying COVID-19
4,650 Patients Enrolled for COVID-19
David Landers, MDPrincipal InvestigatorHackensack Meridian Health

Media Library

Metoprolol Succinate (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT05096884 — Phase < 1
COVID-19 Research Study Groups: Study arm - Metoprolol Succinate.
COVID-19 Clinical Trial 2023: Metoprolol Succinate Highlights & Side Effects. Trial Name: NCT05096884 — Phase < 1
Metoprolol Succinate (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05096884 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Have there been other investigations concerning the efficacy of Metoprolol Succinate?

"Currently, 21 trials examining the efficacy of Metoprolol Succinate are underway with 4 in Phase 3. Although most studies take place in Orlando, Florida there are a total of 144 sites conducting research on this medication."

Answered by AI

What therapeutic applications is Metoprolol Succinate typically used for?

"Metoprolol Succinate is a popular choice for hemodynamically stable patients, as well as those with angina pectoris, atrial fibrillation or hypertensive disease."

Answered by AI

Does my medical history qualify me to join this research endeavor?

"We are in search of 20 participants aged 18-40 who have been suffering from tachycardia and/or dyspnea with minimal activity for 3 to 12 months. Additionally, the abnormal results on a HUTT (heads up tilt test) should be noted upon application."

Answered by AI

Are there any enrollments still available for participants?

"According to clinicaltrials.gov, this health research project is currently in search of suitable participants. This study was initiated on March 23rd 2022 and revised two days later."

Answered by AI

How many participants have enrolled in this experiment thus far?

"Confirmed. Clinicaltrials.gov data supports the fact that this clinical trial is currently admitting patients, with the first posting being made on March 23rd 2022 and most recent update occurring two days later. The study needs to fill 20 positions at a single location."

Answered by AI

Is enrollment open to those younger than 85 years of age for this research?

"The eligibility requirements for this study necessitate that applicants must be between the ages of 18 and 40. In contrast, there are 157 trials available to minors while 1047 studies permit those beyond retirement age."

Answered by AI

Who else is applying?

What state do they live in?
Florida
How old are they?
65+
What portion of applicants met pre-screening criteria?
Did not meet criteria
What site did they apply to?
Hackensack Univeristy Medical Center
Recent research and studies
~5 spots leftby Mar 2025