This trial is evaluating whether 18F-fluciclovine will improve 3 primary outcomes in patients with Pancreatitis, Graft. Measurement will happen over the course of These reviews will take place within 72 hours of the radiologic imaging taking place for each participant..
This trial requires 60 total participants across 1 different treatment group
This trial involves a single treatment. 18F-fluciclovine is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Primary pancreatitis can be caused by gallstones, hypertriglyceridemia and hyperglycemia, alcohol, NSAIDs, and [benign] gallstone disease. In secondary pancreatitis there are many causes and they can be caused by a multitude of different factors. Chronic pancreatitis occurs from several types of chronic pancreatitis. For further information visit www.paincreekonline.com:primary_pancreatitis/" - Anonymous Online Contributor
"Approximately 381,400 new diagnoses of acute pancreatitis will be recorded by 2030 in the United States. As an older population is diagnosed with diabetes, the number of new cases of chronic pancreatitis is expected to increase." - Anonymous Online Contributor
"It is not possible to cure or prevent recurrent acute pancreatitis in the majority of patients. However, symptomatic treatment is effective in managing the debilitating symptoms associated with ongoing pancreatitis. At 5 years the majority of patients no longer require hospitalised care." - Anonymous Online Contributor
"Pancreatitis is a disease of the pancreas with a spectrum of signs and symptoms. Typically in older adults, pancreatitis is associated with a history of gallstones or alcoholism." - Anonymous Online Contributor
"The following signs point to a diagnosis of acute pancreatitis: vomiting blood, nausea or vomiting, lethargy, swollen fingers or toes, abdominal pain, bloody diarrhea, dehydration, low body temperature, and a positive Murphy's sign. The following other signs point to a diagnosis of chronic pancreatitis: unintentional weight loss, excessive thirst, inability to eat, and jaundice." - Anonymous Online Contributor
"The most common treatment for acute pancreatitis is fluid replacement. In more serious cases, parenteral nutrition is often used to support the body after a severe bout of injury, and insulin is prescribed for pancreatic- insufficiency. These are not all of the usual treatments for pancreatitis.\n" - Anonymous Online Contributor
"Pancreatitis is a complex disease (i.e., multiple factors are at least theoretically possible causes), with many possible etiologies. Genetic factors influencing several etiologies may be present. Atypical presentations and lack of definitive diagnostic criteria, such as diagnostic guidelines, may complicate the diagnostic analysis. At the present time, treatment is tailored after thorough workup of all known causes. The future may bring more precise etiologic links between pancreatitis and specific infectious, toxic, and systemic factors." - Anonymous Online Contributor
"Treatment with FDG-18F-FLU is currently used very rarely. However, due to the high rate of side effects, the clinical data demonstrating the superiority of FDG-18F-FLU in combination treatments do not justify the current low usage." - Anonymous Online Contributor
"It is suggested that MDR1 gene polymorphism is not an independent prognostic factor for the long-term outcome in APACHE II-staged children with inflammatory bowel disease. However, it seems to be significantly and independently associated with short-term response to (18)F-flucrifoxine therapy. An earlier initiation of therapy might also have improved the response." - Anonymous Online Contributor
"A study of the pharmacokinetics and pharmacodynamics of 18f-FLU in patients with pancreatitis showed a mean plasma concentration of the drug of 0.2 ng/mL. Therefore, the observed differences in the pharmacodynamics between studies could be explained by differences in treatment regimes and the time intervals between the administration of the drug. The fact that this study failed to show statistical correlation between 18f-FLU levels and patient outcome in pancreatitis suggests that this agent is not clinically useful in acute pancreatitis." - Anonymous Online Contributor
"There are significant numbers of patients who are hospitalized for severe symptoms and complications who are never diagnosed with pancreatitis. Patients without conclusive signs, symptoms, or laboratory findings for pancreatitis could be treated medically with NSAIDs and oral analgesics." - Anonymous Online Contributor
"Most clinical trials testing new therapies for chronic pancreatitis are restricted to patients who have mild disease or have endoscopic remission after initial therapy. Clinical trials that do offer treatment would be most appropriate for mild disease. Patients with severe or unremitting disease would be candidates for some clinical trials." - Anonymous Online Contributor