This trial is evaluating whether Radiation therapy of unresected keloids will improve 1 primary outcome and 1 secondary outcome in patients with Safety and Efficacy of Radiation Therapy for the Treatment of Keloids. Measurement will happen over the course of 10 weeks.
This trial requires 15 total participants across 1 different treatment group
This trial involves a single treatment. Radiation Therapy Of Unresected Keloids is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"In the present study, topical antifibroblast and oral anti-fibroblast therapies were found to be effective and safe in the treatment of keloids. In view of the side effects encountered during therapy and lack of consistency of the long-term results seen in the literature, and without knowing the exact mechanisms of the keloids, we consider topical and oral therapies to be of high value in the treatment of keloids and recommend combined use of both in cases where other therapies are ineffective." - Anonymous Online Contributor
"There is a clear relationship between keloid and psoriasis. This relationship is not necessarily related to the causal factors of the comorbidities. For cosmetic purposes we believe it is possible to manage keloid effectively, however, no clinical evidence was found of keloid cure." - Anonymous Online Contributor
"Keloids are skin conditions that typically develop on the body and are characterized by hard nodules, plaques and scarring. This scarring tends to interfere with blood circulation and cause local discomfort. Keloids can affect people of all ethnic backgrounds but are common among Asians.\n" - Anonymous Online Contributor
"The major cause of keloid is lack of skin immunity. Other factors like age, genetics and occupational exposure can also play a role and the overall picture of the cause of a keloid is more complex than a simple cause and effect relationship." - Anonymous Online Contributor
"Data from a recent study provides the first overview of the signs of keloid, which should help physicians to confirm the diagnosis and treatment of keloid." - Anonymous Online Contributor
"Keloid was found in 12% of American children and 20% of adults. The percentage presenting with keloid-like disease is significantly greater in women in the United States. This finding may be related to the increased exposure of US women to topical agents during pregnancy and/or breast feeding. This is the first report of keloid-like disease of American patients." - Anonymous Online Contributor
"The development of new drugs for keloid seems a lot distant. However, there are some good drugs that have shown promising results. For instance, retinoid can help reduce inflammation and keloid scarring. Additionally, an anti-inflammatory drug such as etanercept also shows promise in the keloid treatment." - Anonymous Online Contributor
"[The average age people get keloid lesions is 37.8 years old (SD = 5.9), which is much earlier than what has been reported. Older age might suggest an increase in keloid burden as a result of cumulative risk factors like cumulative cumulative lifetime trauma exposures, earlier onset of exposures or time of onset, or increased duration of exposure] (http://www.researchexposergists.com/research/index.php/keloids/keloids-by-age/keloid-over-the-years.) A more recent study has [noted] that keloids are more common in older patients, with an average age of 30 at first symptom onset (SD = 12)." - Anonymous Online Contributor
"A new treatment modality for local control of the keloids with high dose radiation therapy using IMRT was presented that gives excellent local control and no serious side effects. Further clinical studies are needed." - Anonymous Online Contributor
"There is suggestive evidence of strong genetic predisposition to keloid, as indicated by the presence of a positive family history of keloid, and no significant difference in the occurrence of keloid in the two groups." - Anonymous Online Contributor
"There is a substantial discrepancy of keloid patients eligible for clinical trial. Therefore, keloid patients who are not eligible for clinical trials are the one being considered for clinical trials, which can be minimized by improving the communication in the clinical practice." - Anonymous Online Contributor
"Although most patients with keloids treated with radiation therapy develop scars, some patients develop keloid scars. Scar development may be minimized by avoidance of scar enhancing drugs, use of non-irradiated skin, and long-lasting use of a scar-reducing plastic wrap." - Anonymous Online Contributor