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Hormone Therapy

Insulin for Insulin Resistance

Phase < 1
Waitlist Available
Led By Jacqueline L Limberg, Ph.D.
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
non-nicotine users;
healthy adult men and women;
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline at minute 60
Awards & highlights

Study Summary

This trial will study whether high levels of insulin in the blood can reduce the constriction of blood vessels in the legs.

Eligible Conditions
  • Insulin Resistance
  • Vasoconstriction
  • Healthy Subjects

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline at minute 60
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline at minute 60 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amount of leg blood flow
Secondary outcome measures
Amount of cerebral blood flow
Amount of muscle sympathetic nerve activity (MSNA)

Side effects data

From 2015 Phase 4 trial • 156 Patients • NCT02002221
13%
Nasopharyngitis
10%
Hyperhidrosis
9%
Hunger
9%
Tremor
8%
Asthenia
6%
Hypoglycaemia
1%
Squamous cell carcinoma of the tongue
1%
Femoral neck fracture
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vildagliptin (LAF237)
Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: InsulinExperimental Treatment1 Intervention
Participants will complete a 60 minute hyperinsulinemic-euglycemic infusion.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Insulin human
FDA approved

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
360 Previous Clinical Trials
627,936 Total Patients Enrolled
10 Trials studying Insulin Resistance
360 Patients Enrolled for Insulin Resistance
Jacqueline L Limberg, Ph.D.Principal InvestigatorUniversity of Missouri-Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would individuals of advanced age be suitable candidates for this research project?

"The clinical trial necessitates that patients are between the ages of 18 and 45. There is also a separate study taking place for those under 18, with 76 trials in total, while 462 other studies focus on individuals over 65 years old."

Answered by AI

Are there any eligibility criteria that would preclude me from enrolling in this research project?

"This research project is enrolling 30 individuals who are between 18 and 45 years old and have insulin resistance. Additionally, the requisite criteria for enrollment include being a healthy adult male or female; having a BMI of 18-30 kg/m2; not pregnant or breastfeeding; and abstaining from nicotine use."

Answered by AI

Is recruitment of participants still open for this scientific experiment?

"Unfortunately, this clinical trial is not currently recruiting new candidates. Initially posted on August 6th 2020 and last updated on February 7th 2022, the study has ceased to look for participants; despite that fact, there are still 999 other trials actively searching for patients."

Answered by AI
~6 spots leftby Mar 2025