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Immunomodulator

Abatacept for Type 1 Diabetes

Phase < 1
Waitlist Available
Research Sponsored by Carla Greenbaum, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
≤ 7 months from type 1 diabetes diagnosis based on ADA criteria
> 21 days from type 1 diabetes diagnosis or metabolically stable per study physician assessment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 to 2 weeks
Awards & highlights

Study Summary

This trial is testing if a short-course of abatacept can help regulate the immune system in people with newly diagnosed Type 1 diabetes.

Eligible Conditions
  • Type 1 Diabetes

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 to 2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 to 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in B-cell transcriptional module (CD19.mod) (composite score)
Change in EOMES CD8 whole blood gene expression signature (composite score)
Change in frequency of B cells within total PBMC (%)
+4 more

Side effects data

From 2023 Phase 3 trial • 613 Patients • NCT03086343
6%
URINARY TRACT INFECTION
5%
UPPER RESPIRATORY TRACT INFECTION
5%
NASOPHARYNGITIS
3%
HYPERTENSION
100%
80%
60%
40%
20%
0%
Study treatment Arm
Abatacept
Upadacitinib 15 mg

Trial Design

1Treatment groups
Experimental Treatment
Group I: AbataceptExperimental Treatment1 Intervention
Abatacept will be given by a subcutaneous (SC) formulation weekly for three months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Abatacept
FDA approved

Find a Location

Who is running the clinical trial?

Juvenile Diabetes Research FoundationOTHER
231 Previous Clinical Trials
111,691 Total Patients Enrolled
Carla Greenbaum, MDLead Sponsor
2 Previous Clinical Trials
26 Total Patients Enrolled
Medical College of WisconsinOTHER
604 Previous Clinical Trials
1,162,196 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~15 spots leftby Mar 2025