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Immunomodulator
Abatacept for Type 1 Diabetes
Phase < 1
Waitlist Available
Research Sponsored by Carla Greenbaum, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
≤ 7 months from type 1 diabetes diagnosis based on ADA criteria
> 21 days from type 1 diabetes diagnosis or metabolically stable per study physician assessment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 to 2 weeks
Awards & highlights
Study Summary
This trial is testing if a short-course of abatacept can help regulate the immune system in people with newly diagnosed Type 1 diabetes.
Eligible Conditions
- Type 1 Diabetes
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 0 to 2 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 to 2 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in B-cell transcriptional module (CD19.mod) (composite score)
Change in EOMES CD8 whole blood gene expression signature (composite score)
Change in frequency of B cells within total PBMC (%)
+4 moreSide effects data
From 2023 Phase 3 trial • 613 Patients • NCT030863436%
URINARY TRACT INFECTION
5%
UPPER RESPIRATORY TRACT INFECTION
5%
NASOPHARYNGITIS
3%
HYPERTENSION
100%
80%
60%
40%
20%
0%
Study treatment Arm
Abatacept
Upadacitinib 15 mg
Trial Design
1Treatment groups
Experimental Treatment
Group I: AbataceptExperimental Treatment1 Intervention
Abatacept will be given by a subcutaneous (SC) formulation weekly for three months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Abatacept
FDA approved
Find a Location
Who is running the clinical trial?
Juvenile Diabetes Research FoundationOTHER
231 Previous Clinical Trials
111,691 Total Patients Enrolled
Carla Greenbaum, MDLead Sponsor
2 Previous Clinical Trials
26 Total Patients Enrolled
Medical College of WisconsinOTHER
604 Previous Clinical Trials
1,162,196 Total Patients Enrolled
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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