Pain, Stress and Emotions for Chronic Pain

Phase-Based Estimates
1
Effectiveness
1
Safety
Stanford University, Palo Alto, CA
Chronic Pain
Pain, Stress and Emotions - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Chronic Pain

Study Summary

This study is evaluating whether a pain psychology class can help people with chronic pain.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Pain, Stress and Emotions will improve 1 primary outcome, 11 secondary outcomes, and 2 other outcomes in patients with Chronic Pain. Measurement will happen over the course of Change from baseline to 1-Month follow-up (with secondary 2-month follow-up).

Change from baseline to 1-Month follow-up (with secondary 2-month follow-up)
Ambivalence over Emotional Expression (AEQ)
Emotion-Approach Coping
Pain Attributions Questionnaires
Pain Bothersomeness
Pain Catastrophizing Scores; measured with Pain Catastrophizing Scale
Pain Intensity NRS
Patient-Reported Outcomes Measurement Information System: Anxiety 6a
Patient-Reported Outcomes Measurement Information System: Depression 6a
Patient-Reported Outcomes Measurement Information System: Pain Interference short form 6a
Patient-Reported Outcomes Measurement Information System: Physical Function 8b
Patient-Reported Outcomes Measurement Information System: Sleep Disturbance 6a
Patient-Reported Outcomes Measurement Information System: anger 5a
Patient-Reported Outcomes Measurement Information System: fatigue 6a
Patient-Reported Outcomes Measurement Information System: social isolation 6a

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
Pain, Stress, & Emotions Class

This trial requires 120 total participants across 2 different treatment groups

This trial involves 2 different treatments. Pain, Stress And Emotions is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.

Pain, Stress, & Emotions Class
Behavioral
No active or placebo comparator will be used. This is a single-arm study design.
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change from baseline to 1-month follow-up (with secondary 2-month follow-up)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change from baseline to 1-month follow-up (with secondary 2-month follow-up) for reporting.

Who is running the study

Principal Investigator
M. Z.
Maisa Ziadni, Principal Investigator
Stanford University

Closest Location

Stanford University - Palo Alto, CA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Chronic pain condition (pain > 3 months)
Access to the internet
English fluency

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get chronic pain a year in the United States?

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The prevalence of chronic pain in the US general population is high, with most individuals reporting the condition. There is considerable variability in prevalence across geographic regions and racial/ethnic groups. This raises critical questions regarding the effectiveness of prevention campaigns and strategies based on estimates of the current prevalence of chronic pain.

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What is chronic pain?

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Chronic pain is often persistent and long term. A number of people are affected by this condition, with many needing treatment. It may also affect family relationships and quality of life. The economic cost of chronic pain is significant.

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What causes chronic pain?

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Pain is an unavoidable symptom of the human condition and can have various causes. The diagnosis is complicated by the fact that many people present with multiple pain syndromes. A pain assessment is important to make the diagnosis of a pain syndrome in the proper context and to choose the treatment approach to the particular pain disorder.

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What are the signs of chronic pain?

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Most people will have had symptoms of pain for several years, but for the majority of people there will be no history of chronic pain and it is only when specific types of pain occur that the diagnosis of chronic pain becomes possible.\nKey words\nChronic pain\nProgressive chronic pain\nPatient's perspective\nThe use of self-report questionnaires to collect information on patients' symptoms of chronic pain has been used extensively. This method offers a number of advantages, such as the option of measuring both pain intensity and pain related functional impairment and of measuring the effects of pain on the patient's life as well as detecting chronic pain with high reliability compared to objective assessments by an assessment clinic.

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Can chronic pain be cured?

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In a recent study, findings of this preliminary study suggest that chronic pain can be effectively and safely reduced or eliminated by using a combination of behavioral and complementary/alternative medicine methods.

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What are common treatments for chronic pain?

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Chronic pain is treated by treating the painful sensation. This can be achieved by a wide variety of treatment options, including psychosocial interventions, physical therapy, pain treatments, and pharmaceutical treatments. Many chronic pain patients require multidisciplinary treatment approaches. As medical care is becoming more advanced and specialized, there is an increasing use in chronic pain treatment of cognitive behavioral therapy, graded exercise therapy, and other treatments that strengthen the patient's resiliency. Further research is necessary to answer the question of whether the treatment of comorbid chronic pain is a function of a specific mental state or whether it represents any kind of psychologic dimension.

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How serious can chronic pain be?

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Chronic pain is as disabling as any other occupational disability and there may be an expectation that people with chronic pain can only be'minding their pain' which the law needs to address.

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Who should consider clinical trials for chronic pain?

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This article provides important baseline data on chronic pain management and clinical trial participation to inform the discussion of who should participate in a clinical trial for chronic pain. The article provides information regarding clinical trial eligibility criterion based upon evidence regarding comorbidities, severity of chronic pain, and treatment-related considerations for all age groups. The article aims to inform the discussion about who should be part of a clinical trial for chronic pain, as well as the methods to identify the most effective treatments for chronic pain.

Unverified Answer

What does pain, stress and emotions usually treat?

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Most of our patients said that they usually tried medications. I felt that my patients may have been under-dosed with opioids, particularly those whose pain level was too low, and thus may have been unable to be treated effectively. I tried to take it into account to treat the patients as generously as I could. I was under the impression that opioids can be very dangerous. I used the same amount of opioids in different patients and I couldn't find any correlation between that and the number of adverse events my patients experienced. But there still were adverse events, particularly in the first few months.

Unverified Answer

Does pain, stress and emotions improve quality of life for those with chronic pain?

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This qualitative study identifies three ways in which stress, pain, and/or negative emotions might be alleviated, and their potential utility in the promotion of physical activity among those with chronic pain. This article is protected by copyright. All rights reserved.

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What are the common side effects of pain, stress and emotions?

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It is impossible to know what will happen to the majority of persons in the real world. However, there are certain common side effects of pain, stress, and emotions which clinicians or other specialists have studied and reported on. We discuss these here in our blog entries. All of the side effects of pain, stress, and emotions are common but many of them were found in studies which were only a few years old. Most of these studies were published in the context of psychiatric and/or mental health professions which may be more conservative than we. The side effect information in this article is based on what is currently in the specialty medical literature.

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Has pain, stress and emotions proven to be more effective than a placebo?

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In addition to showing some evidence for a small but statistically significant pain-reducing effect, CEA and PEA showed a benefit relative to a placebo on subjective feelings of wellbeing, perceived stress, and mood. This may explain the positive outcome of CEA and PEA. Findings from a recent study of our study do not yet provide an explanation for the effect for subjective measures of health (for example objective disability measures). Findings from a recent study of our study also suggest a potentially beneficial effect for CEA and PEA, which would be an important finding for anesthesiologists and pain therapists.

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