CLINICAL TRIAL

Zinc Gluconate for Inflammation

Recruiting · 18+ · All Sexes · Cleveland, OH

This study is evaluating whether zinc supplementation can improve inflammation, metabolic, and cardiovascular risk among HIV infected patients on stable anti-retroviral therapy.

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About the trial for Inflammation

Eligible Conditions
Inflammation · Cardiovascular Diseases · Zinc Deficiency

Treatment Groups

This trial involves 4 different treatments. Zinc Gluconate is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.

Experimental Group 1
Zinc Gluconate
DRUG
Control Group 2
Placebo
DRUG
Control Group 3
matching placebo
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About The Treatment

Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Zinc gluconate
FDA approved

Eligibility

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Male or Female age ≥18 years
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: baseline and 24 Weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: baseline and 24 Weeks.
View detailed reporting requirements
Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Zinc Gluconate will improve 1 primary outcome in patients with Inflammation. Measurement will happen over the course of baseline and 24 Weeks.

Effect of zinc supplementation in HIV-infected subjects
BASELINE AND 24 WEEKS
Changes in markers of inflammation and immune activation by measuring momonocyte activation soluble markers CD14 (sCD14), high sensitivity C reactive protein (hsCRP), and soluble tumor necrosis alpha receptor I and II (sTNFR-I and II)

Who is running the study

Principal Investigator
G. M.
Grace McComsey, Principal Investigator
University Hospitals Cleveland Medical Center

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can inflammation be cured?

The current model of inflammation and its association with cancer fails to replicate in many cases. This is likely due to the large range of factors influencing inflammatory processes.

Anonymous Patient Answer

What causes inflammation?

There are many inflammation-related diseases that are not adequately described as "inflammation" in the medical literature. These disorders range from mild chronic fatigue to serious autoimmune illnesses. It is not surprising that a variety of disparate diseases share some of these features. One of the best known disorders associated with inflammation is fibromyalgia, but these disorders are vastly under-reported in both the medical literature and in clinical practice, especially in the United States. The list of disorders arising from inflammation is an incomplete list. Given the extensive list, it is evident that a fundamental lack of understanding of inflammation exists in medicine, science, and public health.

Anonymous Patient Answer

What is inflammation?

The inflammatory response occurs as an acute phase response in the tissue in an attempt to eliminate the causative agent or a secondary pathogenic mechanism of infection or injury. Inflammatory cascade signalling starts from a sensor/activator protein located at the cell surface or within a cellular compartment. At a given location of an inflamed tissue, the inflammatory cascade is triggered by a diverse set of activating molecules (e.g. histamine), which act as chemo-attractants. The inflammatory process is accompanied with tissue mobilization, vascular leakage and extravasation of blood-borne inflammatory cells. An acute and non-acute phase response is involved in the inflammatory response.

Anonymous Patient Answer

What are the signs of inflammation?

There are non-specific signs of inflammation. One example is the white patch on the cornea as a result of a corneal ulcer. Other signs of inflammation include high red blood cell levels, abnormal blood cell levels, elevated white blood cell levels, and the presence of antibodies against different kinds of infections.

Anonymous Patient Answer

What are common treatments for inflammation?

There are many similarities in terms of diagnosis and treatment between RA, SjO and PsA patients. Thus, for treating these diseases, it seems appropriate to follow international guidelines.

Anonymous Patient Answer

How many people get inflammation a year in the United States?

About 500,000 people get rheumatic disease, and about 250,000 get inflammation a year in the United States. Both conditions are associated with higher rates of mortality and higher expenses for society.

Anonymous Patient Answer

Does inflammation run in families?

This case report describes a familial inflammatory bowel disease susceptibility mutation in MYBD1/NFYA gene; the first genetic discovery in this gene. NFYA encodes a nuclear factor essential for cytokine gene induction. Although previous associations of MYBD1 and/or MYBD2/MYD88 with a number of inflammatory diseases are reported, the identification of a novel MYBD1/NFYA gene mutation in these patients contributes to the knowledge of both MYDs on signal transduction in the host cell and their implication in the pathogenesis of the disease. Further studies of the MYDs in familial inflammatory diseases are required.

Anonymous Patient Answer

What is the average age someone gets inflammation?

The average age of inflammation in adults is 47 years in the United States, including age of onset of 1.7 ± 2.2 years. In a recent study, findings reinforces that inflammatory diseases are common in both adults and children, and that age of onset for inflammatory diseases was found to be higher than previously reported.

Anonymous Patient Answer

Has zinc gluconate proven to be more effective than a placebo?

Zinc gluconate has been shown to relieve symptoms of oral ulcer inflammation in this randomized, double-blind, placebo-controlled trial. The data from this clinical trial should be taken into account when considering therapeutic application.

Anonymous Patient Answer

What does zinc gluconate usually treat?

Zinc gluconate injection is a fast-acting, long-lasting, and safe treatment for localized oral infection or swelling of the mouth. For severe infections, antibiotic treatment is used first.

Anonymous Patient Answer

Have there been other clinical trials involving zinc gluconate?

ZnSO4 is effective in the treatment of acute bacterial skin and soft tissue infections, at moderate doses. There have not been many clinical trials involving zinc sulfate.

Anonymous Patient Answer

What are the latest developments in zinc gluconate for therapeutic use?

Zinc gluconate is an effective topical antibacterial agent for the prophylaxis and treatment of acute or chronic skin and soft tissue infections in humans. Zinc gluconate may also be of benefit for the palliative management of cutaneous ulcers. Importantly, zinc gluconate has been shown to be well tolerated and has an excellent safety record, which is demonstrated by its use for over 50 years. Importantly, recent studies do not support the use of zinc gluconate in the prophylaxis of oral squamous cell carcinomas.

Anonymous Patient Answer
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