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Cyclin-Dependent Kinase Inhibitor

Letrozole for Endometrial Adenocarcinoma

Phase < 1
Waitlist Available
Led By Emma Barber, MD, MS
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
(Please note: Given the amount of tissue obtained from these specimens is often much more than a core needle biopsy, we do not anticipate difficulties with insufficient tissue.)
Patients may receive erythrocyte transfusions to achieve this hemoglobin level at the discretion of the investigator. Initial treatment must not begin earlier than the day after the erythrocyte transfusion.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at day 15
Awards & highlights

Study Summary

This trial is studying how well abemaciclib and letrozole work in treating patients with endometrial cancer.

Eligible Conditions
  • Endometrial Endometrioid Adenocarcinoma

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
The amount of tissue needed for the study will be obtained through a biopsy, which should provide enough tissue for the study.
Select...
If your hemoglobin levels are too low, you may receive a blood transfusion to increase them. However, the treatment cannot start until the day after the transfusion.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at day 15
This trial's timeline: 3 weeks for screening, Varies for treatment, and at day 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Ki-67 expression
Secondary outcome measures
Biological characteristics of tumors: MMR status
Neoplasms
Biological characteristics of tumors: expression of cyclin D1
+4 more

Side effects data

From 2018 Phase 4 trial • 79 Patients • NCT02137538
10%
Fracture
8%
Acne
5%
Scoliosis
3%
Hair loss
3%
Sacroiliitis
3%
Neuro event
100%
80%
60%
40%
20%
0%
Study treatment Arm
Anastrozole
Letrozole

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (letrozole, abemaciclib)Experimental Treatment3 Interventions
Patients receive letrozole PO QD and abemaciclib PO BID on days 1-14. Patients then undergo standard of care hysterectomy on day 15.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Abemaciclib
FDA approved
Letrozole
FDA approved
Therapeutic Conventional Surgery
2005
Completed Phase 3
~9860

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,609 Previous Clinical Trials
40,915,619 Total Patients Enrolled
Northwestern UniversityLead Sponsor
1,576 Previous Clinical Trials
911,895 Total Patients Enrolled
Emma Barber, MD, MSPrincipal InvestigatorNorthwestern University
3 Previous Clinical Trials
297 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are allowed to register for this research project?

"Affirmative. The information on clinicaltrials.gov demonstrates that this research is presently recruiting candidates. This investigation, which was initiated on August 12th 2019, needs 27 participants from two sites to be enrolled."

Answered by AI

Has recruitment for this experiment begun?

"This clinical trial remains open for recruitment, as per the information on clinicaltrials.gov. This medical study was initially posted to the platform on August 12th 2019 and had its most recent update April 30th 2021."

Answered by AI

Has Letrozole been studied and analyzed in other scientific experiments?

"Currently, there are 228 clinical trials for Letrozole that have been initiated. Of these studies, 50 are in Phase 3. San Francisco is the most popular location conducting research into this treatment but other sites across America also exist - 15288 to be exact."

Answered by AI

In which medical cases is Letrozole generally utilized?

"Letrozole is a frequently prescribed therapy for treating breast cancer, but it has also been effectively used to manage anovulatory cycle and tamoxifen-resistant conditions."

Answered by AI
~5 spots leftby Mar 2025