This trial is evaluating whether Hyperpolarized [13C]Pyruvate will improve 1 primary outcome in patients with Cancer Brain. Measurement will happen over the course of Measurements made during study scan.
This trial requires 28 total participants across 1 different treatment group
This trial involves a single treatment. Hyperpolarized [13C]Pyruvate is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Results from a recent paper suggests that [brain cancer](https://www.withpower.com/clinical-trials/brain-cancer) is probably caused by a complex interaction between genetic factors and environmental exposures, perhaps including smoking or radiation." - Anonymous Online Contributor
"The cause of [brain cancer](https://www.withpower.com/clinical-trials/brain-cancer) is still not fully understood; however, one of the biggest risk factors for developing brain cancer is cigarette smoking, which is the number one cause of death from smoking. The lifetime risk of getting brain cancer is about one in 1,000 if a person smokes all of their life. The lifetime risk of dying from brain cancer is about one in 1,000. Brain cancer is also the 2nd leading cause of cancer death in the UK in adults that have never smoked in their life.\n\n
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"Signs of brain cancer can often be detected with neurological examination, though imaging with CT and MRI can diagnose brain tumours with greater accuracy. There are three common signs of brain cancer which usually lead to an MRI. The most obvious sign of brain cancer is a mass in the brain tissue, which can be visualised on imaging. Other signs include visual disturbance of sensory function, disturbance of language, and behavioural problems." - Anonymous Online Contributor
"There is no evidence that common cancer treatments are effective for treating brain metastasis. Therefore, it is unlikely to be successful if metastatic infiltration of brain parenchyma is responsible for causing the neurological dysfunction, but other mechanisms include the involvement of the vasculature and/or the immune system." - Anonymous Online Contributor
"Every year, 6.9 to 6.7 million Americans are diagnosed with one form of [brain cancer](https://www.withpower.com/clinical-trials/brain-cancer). This makes the brain the most common or second most common type of cancer in American adults." - Anonymous Online Contributor
"There have been advances in management of brain cancers, and, although the disease may no longer be curable, new treatment approaches and techniques may improve outcomes." - Anonymous Online Contributor
"In conclusion, the authors were able to perform preclinical safety assessments with hyperpolarized [13C]pyruvate. In a porcine model of human glioblastoma, hyperpolarized [13C]pyruvate was able to reach a maximum of 9.5 GBq, for a therapeutic dose. The authors recommend further clinical trials of hyperpolarized [13C]pyruvate in a xenograft tumor model of solid human tumors." - Anonymous Online Contributor
"The survival rate of patients diagnosed with [brain cancer](https://www.withpower.com/clinical-trials/brain-cancer) has improved over the past few years. This improvement is likely due to improvements in detection, earlier diagnosis, and improved treatment modalities. Although the long-term survival of patients with brain cancer remains unchanged, this should not be interpreted as a failure of cancer treatment. For many patients with brain cancer (and especially patients diagnosed with benign brain tumours) a full-scale brain tumor treatment is required after the initial surgery to achieve a cure. This is called a “total brain tumor” therapy." - Anonymous Online Contributor
"In this series, high-dose (2.0-mg/kg dose-rate infusion) infusion of 13C-pyruvate significantly impacted clinical and biological variables without significant toxicity or QOL deterioration related to hyperpolarization dose. A dose-escalation trial is currently planned to test the value of hyperpolarized 13C-pyruvate in evaluating the clinical response for patients with diffusely infiltrating glioma." - Anonymous Online Contributor
"The hyperpolarized pyruvate is not an oxygen diffusion blocking compound, and should not be used as a metabolic control at a time when the tumors are growing and the glucose uptake is very high. Pyruvate has to be hyperpolarized in order to exert a significant impact on the glucose metabolism in the tumors." - Anonymous Online Contributor
"The incidence of primary brain cancer continues to increase in all age groups, and the mortality from brain cancer also increased, so the seriousness of the disease should not be ignored." - Anonymous Online Contributor
"It is extremely important to make the decision regarding clinical trials before starting treatment or even at the beginning of a treatment plan. The type of treatment the patient has and their wishes also need to be taken into account. In general, patients who are at high risk for relapse are the best candidates for clinical trial, whereas patients with low-risk of relapse do not qualify for clinical trials." - Anonymous Online Contributor