Popular filter options for her2 positive breast cancer trials
Breast Cancer Clinical Trials
View 74 Breast Cancer medical studies.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
LABC Clinical Trials
View 74 LABC medical studies.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
ER Positive Clinical Trials
View 25 ER positive medical studies.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
Monoclonal Antibodies
Combination Therapy for Breast Cancer
This trial is testing a new combination of drugs to treat metastatic hormone receptor-positive, HER2-positive breast cancer. The goal is to establish the safety and efficacy of this new combination and to examine potential biomarkers of response to the treatment.
Monoclonal Antibodies
Immunotherapy Combinations for Breast Cancer
This trial is testing different combinations of immunotherapy drugs to see which are the most effective at treating HR-positive, HER2-negative breast cancer that has progressed after treatment with a CDK4/6 inhibitor.
HER2 Positive Clinical Trials
View 20 HER2 positive medical studies.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Ibrutinib + Trastuzumab for Breast Cancer
This trial is testing ibrutinib given with trastuzumab to see if it is safe and what the highest dose that can be given is. It is for people with HER2-positive metastatic breast cancer that has gotten worse after other treatments.
Monoclonal Antibodies
Combination Therapy for Breast Cancer
This trial is testing a new combination of drugs to treat metastatic hormone receptor-positive, HER2-positive breast cancer. The goal is to establish the safety and efficacy of this new combination and to examine potential biomarkers of response to the treatment.
Procedure
PF-07220060 for Solid Cancers
This trial is testing a new drug, PF-07220060, to see if it is safe and effective when used alone or in combination with other drugs. The trial will be conducted in four parts, with escalating doses in the first part to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). The second part of the trial will test the drug in combination with two different endocrine therapies (letrozole and fulvestrant). The third part of the trial will assess the food effect of the RP2D dose from Part 1A. The fourth part of the trial will be an expansion for combination
Phase 3 Her2 Positive Breast Cancer Clinical Trials
View 74 phase 3 her2 positive breast cancer medical studies.
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
Her2 Positive Breast Cancer Clinical Trials With No Placebo
View 74 her2 positive breast cancer medical studies that do not have a placebo group.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
View More Her2 Positive Breast Cancer Trials
See another 52 medical studies focused on her2 positive breast cancer.
Frequently Asked Questions
Introduction to her2 positive breast cancer
What are the top hospitals conducting her2 positive breast cancer research?
Cutting-edge research and clinical trials are crucial in the quest to conquer her2 positive breast cancer, a subtype known for its aggressive nature. In Boston, Dana-Farber Cancer Institute leads the charge with nine active trials dedicated specifically to her2 positive breast cancer. These trials build upon an impressive history of 218 completed studies since their first recorded trial back in 1998. Not far behind, Memorial Sloan Kettering Cancer Center in New york has seven ongoing trials and an astounding 219 all-time her2 positive breast cancer studies under their belt. Their pioneering efforts date back to 1994, firmly establishing them as a key player in this field.
The Mayo Clinic in Rochester also contributes significantly to understanding and treating her2 positive breast cancer, currently conducting six active clinical trials focused on this specific subtype. With a legacy of 117 previously conducted studies dating back to their first recorded trial in 1998, they continue to make strides towards advancements against this challenging form of breast cancer. In sunny Fort Myers, Florida Cancer Specialists is making noteworthy progress as well with six active clinical trials targeting her2 positive breast cancer. While they have conducted fewer all-time trials than some other institutions (36 total), their dedication since recording their first trial in 1995 cannot be underestimated.
Finally, Florida Cancer Specialists' Saint Petersburg location may be relatively new compared to others on this list but it is equally committed with six ongoing clinical trials solely devoted to combating her2 positive breast cancer; having started at2013-with fifteen previous attempts they are paving the way for future breakthroughs within this evolving field.
These hospitals across different locations signify the collaborative effort required for significant medical advancements aimed at improving outcomes for individuals battling her2 positive breast cancer worldwide
Which are the best cities for her2 positive breast cancer clinical trials?
When it comes to her2 positive breast cancer clinical trials, several cities emerge as frontrunners in research and development. Boston, Massachusetts leads the pack with 37 active trials focusing on treatments like Enzalutamide, Trastuzumab emtansine (T-DM1), and PF-07220060. Nashville, Tennessee closely follows with 35 ongoing studies investigating similar interventions including Enzalutamide and Trastuzumab. Houston, Texas also demonstrates a commitment to advancing care for her2 positive breast cancer patients through their 31 active trials exploring Abemaciclib and Trastuzumab emtansine (T-DM1). New york City rounds out the list of top locations with 31 current studies investigating various treatments such as Imlunestrant and Abemaciclib. Finally, Denver, Colorado showcases its dedication to research by conducting 30 active trials examining innovative approaches like Entinostat and Therapeutic Conventional Surgery. These cities provide valuable opportunities for individuals battling her2 positive breast cancer to participate in cutting-edge clinical trials that may shape the future of treatment options.
Which are the top treatments for her2 positive breast cancer being explored in clinical trials?
The search for effective treatments for HER2 positive breast cancer is a dynamic and evolving field. Promising options currently being explored in clinical trials include:
- Abemaciclib, which is involved in 4 active trials and has been part of 65 all-time her2 positive breast cancer trials since its introduction in 2014.
- Trastuzumab, a well-established treatment with 4 ongoing trials and an impressive track record of 325 all-time her2 positive breast cancer trials since its initiation in 2000.
- Olaparib, another contender making strides with involvement in three active trials and having contributed to the findings of 50 all-time her2 positive breast cancer studies since it was listed as a potential option in 2010.
These innovative treatments hold promise for improving outcomes and quality of life for patients battling this aggressive form of breast cancer.
What are the most recent clinical trials for her2 positive breast cancer?
Recent clinical trials offer promising advancements in the treatment of HER2 positive breast cancer. Phase 2 studies have explored an initial regimen designed to improve outcomes for patients with this subtype of breast cancer. Additionally, a Phase 1 trial investigated the efficacy and safety of injections containing a high dose of viral particles as potential therapy for HER2 positive breast cancer. In Phase 3 trials, two different drugs—imlunestrant and elacestrant—were evaluated for their effectiveness against HER2 positive breast cancer. Moreover, denosumab was studied in a large-scale Phase 3 trial to assess its impact on this specific type of breast cancer. These recent clinical trials provide hope for improved treatment options and outcomes among those affected by HER2 positive breast cancer.
What her2 positive breast cancer clinical trials were recently completed?
Several clinical trials for HER2-positive breast cancer have recently concluded, showcasing the ongoing progress in finding effective treatments. In November 2021, G1 Therapeutics completed a trial investigating Trilaciclib's potential in combating this type of cancer. Concurrently, HiberCell wrapped up a trial exploring Pembrolizumab as a treatment option. Other noteworthy trials include Probiotic, sponsored by Mayo Clinic and completed in July 2021; Buzzy(R), sponsored by University of Wisconsin, Madison and finished in April 2021; LY3484356 from Eli Lilly and Company, also concluded in April 2021. These studies represent important strides forward in understanding and addressing HER2-positive breast cancer to ultimately improve patient outcomes.